Publikationen 2015

  1. Ahmadsei M, Lievens D, Weber C, von Hundelshausen P, Gerdes N. Immune-mediated and lipid-mediated platelet function in atherosclerosis. Curr Opin Lipidol. 2015;26:438-448. Pubmed
  2. Akhtar S, Hartmann P, Karshovska E, Rinderknecht FA, Subramanian P, Gremse F, Grommes J, Jacobs M, Kiessling F, Weber C, Steffens S, Schober A. Endothelial hypoxia-inducible factor-1α promotes atherosclerosis and monocyte recruitment by upregulating microRNA-19a. Hypertension. 2015;66:1220-6. Pubmed
  3. Alampour-Rajabi S, El Bounkari O, Rot A, Müller-Newen G, Bachelerie F, Gawaz M, Weber C, Schober A, Bernhagen J. MIF interacts with CXCR7 to promote receptor internalization, ERK1/2 and ZAP-70 signaling, and lymphocyte chemotaxis. FASEB J. 2015;4497-511. Pubmed
  4. Alard JE, Ortega-Gomez A, Wichapong K, Bongiovanni D, Horckmans M, Megens RT, Leoni G, Ferraro B, Rossaint J, Paulin N, Ng J, Ippel H, Suylen D, Hinkel R, Blanchet X, Gaillard F, D'Amico M, von Hundelshausen P, Zarbock A, Scheiermann C, Hackeng TM, Steffens S, Kupatt C, Nicolaes GA, Weber C, Soehnlein O. Recruitment of classical monocytes can be inhibited by disturbing heteromers of neutrophil HNP1 and platelet CCL5. Sci Transl Med. 2015 ;7:317ra196. Pubmed
  5. Azghandi S, Prell C, van der Laan SW, Schneider M, Malik R, Berer K, Gerdes N, Pasterkamp G, Weber C, Haffner C, Dichgans M. Deficiency of the stroke relevant HDAC9 gene attenuates atherosclerosis in accord with allele-specific effects at 7p21.1. Stroke. 2015;46:197-202. Pubmed
  6. Bäck M, Weber C, Lutgens E. Regulation of atherosclerotic plaque inflammation. J Intern Med. 2015;278:462-82. Pubmed
  7. Bernlochner I, Goedel A, Plischke C, Schüpke S, Haller B, Schulz C, Mayer K, Morath T, Braun S, Schunkert H, Siess W, Kastrati A, Laugwitz KL. Impact of immature platelets on platelet response to ticagrelor and prasugrel in patients with acute coronary syndrome.Eur Heart J. 2015;36:3202-10. Pubmed
  8. Bürger C, Weber C, Lutgens E, Gerdes N. Atherosclerosis: cell biology and lipoproteins-focus on CD40 signaling, PCSK9  and novel animal models. Curr Opin Lipidol. 2015;26:245-246. Pubmed
  9. Curaj A, Wu Z, Fokong S, Liehn EA, Weber C, Burlacu A, Lammers T, van Zandvoort M, Kiessling F. Noninvasive molecular ultrasound monitoring of vessel healing after intravascular surgical procedures in a preclinical setup. Arterioscler Thromb Vasc Biol. 2015;35:1366-73. Pubmed
  10. Döring Y. Not growth but death: GM-CSF/IL-23 axis drives atherosclerotic plaque vulnerability by enhancing macrophage and DC apoptosis. Circ Res. 2015;116:222-4. Pubmed
  11. Döring Y, Drechsler M, Soehnlein O, Weber C. Neutrophils in atherosclerosis: from mice to man. Arterioscler Thromb Vasc Biol. 2015;35:288-95. Pubmed
  12. Drechsler M, de Jong RJ, Rossaint J, Viola J, Leoni G, Wang JM, Grommes J, Hinkel R, Kupatt C, Weber C, Doering Y, Zarbock A, Soehnlein O. Annexin A1 counteracts chemokine-induced arterial myeloid cell recruitment. Circ Res. 2015;116:827-35. Pubmed
  13. Drechsler M, Duchene J, Soehnlein O. Chemokines control mobilization, recruitment, and fate of monocytes in atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35:1050-5. Pubmed
  14. Duchene J, von Hundelshausen P. Platelet-derived chemokines in atherosclerosis. Hamostaseologie. 2015 Jan 16. Hartwig H, Silvestre Roig C, Daemen M, Lutgens E, Soehnlein O. Neutrophils in atherosclerosis. A brief overview. Hamostaseologie. 2015;35:121-7. Pubmed
  15. Hartmann P, Schober A, Weber C. Chemokines and microRNAs in atherosclerosis. Cell Mol Life Sci. 2015;72:3253-66. Pubmed
  16. Hartwig H, Silvestre-Roig C, Hendrikse J, Beckers L, Paulin N, Van der Heiden K, Braster Q, Drechsler M, Daemen MJ, Lutgens E, Soehnlein O. Atherosclerotic plaque destabilization in mice: a comparative study. PLoS One. 2015;10:e0141019. Pubmed
  17. Hartwig H, Silvestre Roig C, Daemen M, Lutgens E, Soehnlein O. Neutrophils in atherosclerosis. A brief overview. Hamostaseologie. 2015;35:121-7. Pubmed

  18. Hinkel R, Lange P, Petersen B, Gottlieb E, Ng JK, Finger S, Horstkotte J, Lee S, Thormann M, Knorr M, El-Aouni C, Boekstegers P, Reichart B, Wenzel P, Niemann H, Kupatt C. Heme Oxygenase-1 gene therapy provides cardioprotection via control of post-ischemic inflammation: an experimental study in a pre-clinical pig model. J Am Coll Cardiol. 2015;66:154-65. Pubmed 
  19. Hoefer IE, Steffens S, Ala-Korpela M, Bäck M, Badimon L, Bochaton-Piallat ML, Boulanger CM, Caligiuri G, Dimmeler S, Egido J, Evans PC, Guzik T, Kwak BR, Landmesser U, Mayr M, Monaco C, Pasterkamp G, Tuñón J, Weber C; ESC Working Group Atherosclerosis and Vascular Biology. Novel methodologies for biomarker discovery in atherosclerosis. Eur Heart J. 2015;36:2635-42. Pubmed
  20. Hristov M, Weber C. Myocardial infarction and inflammation: lost in the biomarker labyrinth. Circ Res. 2015;116:781-3. Pubmed
  21. Hu D, Mohanta SK, Yin C, Peng L, Ma Z, Srikakulapu P, Grassia G, MacRitchie N, Dever G, Gordon P, Burton FL, Ialenti A, Sabir SR, McInnes IB, Brewer JM, Garside P, Weber C, Lehmann T, Teupser D, Habenicht L, Beer M, Grabner R, Maffia P, Weih F, Habenicht AJ. Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity. 2015;42:1100-1115. Pubmed
  22. Ippel H, Miller MC, Berbís MA, Suylen D, André S, Hackeng TM, Cañada FJ, Weber C, Gabius HJ, Jiménez-Barbero J, Mayo KH. 1H, 13C, and 15N backbone and side-chain chemical shift assignments for the 36 proline-containing, full length 29 kDa human chimera-type galectin-3. Biomol NMR Assign. 2015;9:59-63. [Pubmed]
  23. Jamasbi J, Megens RT, Bianchini M, Münch G, Ungerer M, Faussner A, Sherman S, Walker A, Goyal P, Jung S, Brandl R, Weber C, Lorenz R, Farndale R, Elia N, Siess W. Differential inhibition of human atherosclerotic plaque-induced platelet activation by dimeric GPVI-Fc and anti-GPVI antibodies: functional and imaging studies. J Am Coll Cardiol. 2015;65:2404-2415. Pubmed
  24. Karshovska E, Zhao Z, Blanchet X, Schmitt MM, Bidzhekov K, Soehnlein O, von Hundelshausen P, Mattheij NJ, Cosemans JM, Megens RT, Koeppel T, Schober A, Hackeng TM, Weber C, Koenen RR. Hyperreactivity of Junctional Adhesion Molecule A-Deficient platelets accelerates atherosclerosis in hyperlipidemic mice. Circ Res. 2015;116:587-99. Pubmed
  25. Klapproth S, Sperandio M, Pinheiro EM, Prünster M, Soehnlein O, Gertler FB, Fässler R, Moser M. Loss of the Rap-1 effector RIAM results in leukocyte adhesion deficiency due to impaired β2 integrin function in mice. Blood. 2015;126:2704-12. Pubmed
  26. Kornmann LM, Zernecke A, Curfs DM, Janssen BJ, Weber C, de Winther MP, Reneman RS, Hoeks AP, Reesink KD.Echogenic perfluorohexane-loaded macrophages adhere in vivo to activated vascular endothelium in mice, an explorative study. Cardiovasc Ultrasound. 2015;13:1. Pubmed
  27. Kuijpers MJ, Mattheij NJ, Cipolla L, van Geffen JP, Lawrence T, Donners MM, Boon L, Lievens D, Torti M, Noels H, Gerdes N, Cosemans JM, Lutgens E, Heemskerk JW. Platelet CD40L Modulates thrombus growth via phosphatidylinositol 3-kinase β, and not via CD40 and IκB kinase α. Arterioscler Thromb Vasc Biol. 2015;35:1374-81. Pubmed
  28. Kusters PJ, Lutgens E. Cytokines and immune responses in murine atherosclerosis. Methods Mol Biol. 2015;1339:17-40. Pubmed
  29. Legein B, Janssen EM, Theelen TL, Gijbels MJ, Walraven J, Klarquist JS, Hennies CM, Wouters K, Seijkens TT, Wijnands E, Sluimer JC, Lutgens E, Zenke M, Hildner K, Biessen EA, Temmerman L. Ablation of CD8α(+) dendritic cell mediated cross-presentation does not impact atherosclerosis in hyperlipidemic mice. Sci Rep. 2015;5:15414. Pubmed
  30. Leoni G, Neumann PA, Sumagin R, Denning TL, Nusrat A. Wound repair: role of immune-epithelial interactions. Mucosal Immunol. 2015;8:959-68. Pumbed
  31. Leoni G, Neumann PA, Kamaly N, Quiros M, Nishio H, Jones HR, Sumagin R, Hilgarth RS, Alam A, Fredman G, Argyris I, Rijcken E, Kusters D, Reutelingsperger C, Perretti M, Parkos CA, Farokhzad OC, Neish AS, Nusrat A. Annexin A1-containing extracellular vesicles and polymeric nanoparticles promote epithelial wound repair. J Clin Invest. 2015;125:1215-27. Pubmed
  32. Lichtenauer M, Franz M, Fritzenwanger M, Figulla HR, Gerdes N, Jung C. Elevated plasma levels of interleukin-12p40 and interleukin-16 in overweight adolescents. Biomed Res Int. 2015;2015:940910. Pubmed
  33. Lip GY, Weber C. A Happy New Year from Thrombosis and Haemostasis. A 5 year reflection from the Editorial team. Thromb Haemost. 2015;113(1):1-2. Pubmed
  34. Lip GY, Weber C. May your New Year be happy and prosperous with "Thrombosis and Haemostasis". Thromb Haemost. 2015;115:1-2. Pubmed

  35. Lundeberg E, Van Der Does AM, Kenne E, Soehnlein O, Lindbom L. Assessing large-vessel endothelial permeability using near-infrared fluorescence imaging. Arterioscler Thromb Vasc Biol. 2015;35:783-6. Pubmed
  36. Molica F, Morel S, Kwak BR, Rohner-Jeanrenaud F, Steffens S. Adipokines at the crossroad between obesity and cardiovascular disease. Thromb Haemost. 2015;113:553-66. Pubmed
  37. Mandolini C, Santovito D, Marcantonio P, Buttitta F, Bucci M, Ucchino S, Mezzetti A, Cipollone F. Identification of microRNAs 758 and 33b as potential modulators of ABCA1 expression in human atherosclerotic plaques. Nutr Metab Cardiovasc Dis. 2015;25:202-9. [Pubmed]
  38. Mandl M, Drechsler M, Jansen Y, Neideck C, Noels H, Faussner A, Soehnlein O, Weber C, Döring Y. Evaluation of the BDCA2-DTR transgenic mouse model in chronic and acute inflammation. PLoS One 2015;10:e0134176. Pubmed
  39. Medina I, Cougoule C, Drechsler M, Bermudez B, Koenen RR, Sluimer J, Wolfs I, Döring Y, Herias V, Gijbels M, Bot I, de Jager S, Weber C, Cleutjens J, van Berkel TJ, Sikkink KJ, Mócsai A, Maridonneau-Parini I, Soehnlein O, Biessen EA. Hck/Fgr kinase deficiency peduces Plaque growth and stability by blunting monocyte recruitment and intraplaque motility. Circulation. 2015;132:490-501. Pubmed
  40. Megens RT, Bianchini M, Schmitt MM, Weber C. Optical imaging innovations for atherosclerosis research: multiphoton microscopy and optical nanoscopy. Arterioscler Thromb Vasc Biol. 2015;35:1339-46. Pubmed
  41. Megens RT, Soehnlein O. Intravital microscopy for atherosclerosis research. Methods Mol Biol. 2015;1339:41-60. Pubmed
  42. Natarelli L, Schober A. MicroRNAs and the response to injury in atherosclerosis. Hamostaseologie. 2015;35:142-50. Pubmed
  43. Nazari-Jahantigh M, Egea V, Schober A, Weber C. MicroRNA-specific regulatory mechanisms in atherosclerosis. J Mol Cell Cardiol. Pubmed
  44. Njock MS, Cheng HS, Dang LT, Nazari-Jahantigh M, Lau AC, Boudreau E, Roufaiel M, Cybulsky MI, Schober A, Fish JE. Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing anti-inflammatory microRNAs. Blood. 2015;125:3202-12. Pubmed
  45. Pawig L, Klasen C, Weber C, Bernhagen J, Noels H. Diversity and inter-connections in the CXCR4 chemokine receptor/ligand family: molecular perspectives. Front Immunol. 2015;6:429. Pubmed
  46. Renz M, Otten C, Faurobert E, Rudolph F, Zhu Y, Boulday G, Duchene J, Mickoleit M, Dietrich AC, Ramspacher C, Steed E, Manet-Dupé S, Benz A, Hassel D, Vermot J, Huisken J, Tournier-Lasserve E, Felbor U, Sure U, Albiges-Rizo C, Abdelilah-Seyfried S. Regulation of β1 integrin-Klf2-mediated angiogenesis by CCM proteins. Dev Cell. 2015;32:181-190. Pubmed
  47. Santovito D, Egea V, Weber C. DNA methylation and epigenetics: exploring the terra incognita of the atherosclerotic landscape. Eur Heart J. 2015;36:956-8. Pubmed
  48. Santovito D, Weber C. Fibronectin extradomain A: balancing atherosclerotic plaque burden and stability. Thromb Haemost. 2015;114:4. Pubmed
  49. Schober A, Nazari-Jahantigh M, Weber C. MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis. Nat Rev Cardiol. 2015;12:361-74. Pubmed
  50. Selle J, Asare Y, Köhncke J, Alampour-Rajabi S, Shagdarsuren G, Klos A, Weber C, Jankowski J, Shagdarsuren E. Atheroprotective role of C5ar2 deficiency in apolipoprotein E-deficient mice. Thromb Haemost. 2015;114:848-58. Pubmed
  51. Soehnlein O. (Re)solving atherosclerosis. Sci Transl Med. 2015;7:275fs7. Pubmed
  52. Soehnlein O, Ortega-Gómez A, Döring Y, Weber C. Neutrophil-macrophage interplay in atherosclerosis: protease-mediated cytokine processing versus NET release. Thromb Haemost. 2015;114:866-7. Pubmed
  53. Steffens S, Pacher P. The activated endocannabinoid system in atherosclerosis: driving force or protective mechanism? Curr Drug Targets. 2015;16:334-41. Pubmed
  54. Stoppe C, Rex S, Goetzenich A, Kraemer S, Emontzpohl C, Soppert J, Sun Y, Rossaint R, Lue H, Averdunk L, Huang C, Song Y, Pantouris G, Lolis E, Leng L, Schulte W, Bucala R, Weber C, Bernhagen J. Interaction of MIF family proteins in myocardial ischemia/reperfusion damage and their influence on clinical outcome of cardiac surgery patients. Antioxid Redox Signal. 2015;23:865-79. Pubmed
  55. van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E. Blocking CD40-Traf6 interactions by small molecule inhibitor 6860766 ameliorates the complications of diet induced obesity in mice. Int J Obes (Lond). 2015;39:782-90. Pubmed
  56. van Dam AD, Nahon KJ, Kooijman S, van den Berg SM, Kanhai AA, Kikuchi T, Heemskerk MM, van Harmelen V, Lombès M, van den Hoek AM, de Winther MP, Lutgens E, Guigas B, Rensen PC, Boon MR. Salsalate activates brown adipose tissue in mice. Diabetes. 2015;64:1544-54. Pubmed
  57. von Hundelshausen P, Oexle K, Bidzhekov K, Schmitt MM, Hristov M, Blanchet X, Kaemmerer H, Matyas G, Meitinger T, Weber C. Recurrent spontaneous coronary dissections in a patient with a de novo fibrillin-1 mutation without Marfan syndrome. Thromb Haemost. 2015;113:668-70. Pubmed 
  58. van der Vorst EP, Döring Y, Weber C. Chemokines and their receptors in atherosclerosis. J Mol Med (Berl). 2015;93:963-71. Pubmed
  59. van der Vorst EP, Döring Y, Weber C. MIF and CXCL12 in cardiovascular diseases: functional differences and similarities. Front Immunol. 2015;6:373. Pubmed
  60. Van der Vorst EP, Döring Y, Weber C. Chemokines. Arterioskler Thromb Vasc Biol. 2015;35:e52-6. Pubmed
  61. Viola J, Soehnlein O. Atherosclerosis - A matter of unresolved inflammation. Semin Immunol. 2015;27:184-93. Pubmed
  62. Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, Shi MA, He A, Zhou Y, Sukhova GK, Chen H, Cheng XW, Kuzuya M, Murohara T, Zhang J, Cheng X, Jiang M, Shull GE, Rogers S, Yang CL, Ke Q, Jelen S, Bindels R, Ellison DH, Jarolim P, Libby P, Shi GP. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015;21:820-6. Pubmed

  63. Weber C, Lip GY. Editors' Choice papers in Thrombosis and Haemostasis. Thromb Haemost. 2015;113:217-20. Pubmed
  64. Weber C, Hristov M. Atherogenesis and inflammation. From cellular mediators to regulatory mechanisms of inflammation in atherosclerosis. Hamostaseologie. 2015;35:99-101. Pubmed
  65. Wei Y, Zhu M, Corbalan-Campos J, Heyll K, Weber C, Schober A. Regulation of Csf1r and BcI6 in macrophages mediates the stage-specific effects of microRNA-155 on atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35:796-803. Pubmed
  66. Wertenbruch S, Drescher H, Grossarth V, Kroy D, Giebeler A, Erschfeld S, Heinrichs D, Soehnlein O, Trautwein C, Brandenburg LO, Streetz K. The anti-microbial peptide LL-37/CRAMP is elevated in patients with liver diseases and acts as a protective factor during mouse liver injury. Digestion. 2015;91:307-317. Pubmed

  67. Wirtz TH, Tillmann S, Strüßmann T, Kraemer S, Heemskerk JW, Grottke O, Gawaz M, von Hundelshausen P, Bernhagen J.Platelet-derived MIF: A novel platelet chemokine with distinct recruitment properties. Atherosclerosis. 2015;239:1-10. Pubmed
  68. Yamano T, Nedjic J, Hinterberger M, Steinert M, Koser S, Pinto S, Gerdes N, Lutgens E, Ishimaru N, Busslinger M, Brors B, Kyewski B, Klein L. Thymic B cells are licensed to present self antigens for central T cell tolerance induction. Immunity. 2015;42:1048-61. Pubmed
  69. Yin C, Mohanta S, Ma Z, Weber C, Hu D, Weih F, Habenicht A. Generation of aorta transcript atlases of wild-type and apolipoprotein E-null mice by laser capture microdissection-based mRNA expression microarrays. Methods Mol Biol. 2015;1339:297-308. Pubmed
  70. Zarzycka B, Seijkens T, Nabuurs SB, Ritschel T, Grommes J, Soehnlein O, Schrijver R, van Tiel CM, Hackeng TM, Weber C, Giehler F, Kieser A, Lutgens E, Vriend G, Nicolaes GA. Discovery of small molecule CD40-TRAF6 inhibitors. J Chem Inf Model. 2015;55:294-307. Pubmed
  71. Zarzycka B, Nicolaes GA, Lutgens E. Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis. Expert Rev Clin Pharmacol. 2015;8:297-313. Pubmed
  72. Zirlik A, Lutgens E. An inflammatory link in atherosclerosis and obesity. Co-stimulatory molecules. Hamostaseologie. 2015;35:272-8. Pubmed

 

 

 

 
 
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