Publikationen

Original papers:

1. Megens RTA, Reitsma S, Schiffers PHM, Hilgers RHP, De Mey JGR, Slaaf DW, oude Egbrink MGA, van Zandvoort MAMJ. Two-Photon microscopy of vital murine elastic and muscular Arteries. Combined structural and functional imaging with subcellular resolution. J of Vasc Res. 2007;44;87-98.

2. Prinzen L, Miserus RJ, Dirksen A, Hackeng TM, Deckers N, Bitsch NJ, Megens RTA, Douma K, Heemskerk JW, Kooi EM, Frederik PM, Slaaf DW, van Zandvoort MAMJ, Reutelingsperger CP. Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots. Nano Lett 2007;7;93-100.

3. Douma K, Megens RTA, Reitsma S, Prinzen L, Slaaf DW, van Zandvoort MAMJ. Two-photon lifetime imaging of fluorescent probes in intact blood vessels: a window to sub-cellular structural information and binding status. Microsc Res Tech. 2007;70:467-75.

4. Megens RTA, oude Egbrink MGA, Cleutjens JPM, Kuijpers MJE, Schiffers PHM, Merkx M, Slaaf DW, van Zandvoort MAMJ. Imaging collagen in intact viable healthy and atherosclerotic arteries using fluorescently labeled CNA35 and two-photon laser scanning microscopy. Mol Imaging. 2007;6:247-60.

5. Boerboom RA, Krahn KN, Megens RTA, van Zandvoort MAMJ, Merkx M, Bouten CVC. High resolution imaging of collagen organisation and synthesis using a versatile collagen specific probe. J Struct Biol. 2007;159:392-9.

6. Baumann M, Megens RTA, Bartholome R, Dolff S, van Zandvoort MAMJ, Smits JFM, Struijker Boudier HAJ, De Mey JGR. Prehypertensive RAAS blockade in SHR ameliorates long-term vascular function. Hypertens Res. 2007;30:853-61.

7. De Mey J, Megens RTA, Fazzi G. Functional antagonism between endogenous NPY and CGRP in mesenteric resistance arteries. J Pharmacol Exp Ther. 2008;324:930-7.

8. Megens RTA, oude Egbrink MG, Merkx M, Slaaf DW, van Zandvoort MA. Two-photon microscopy on vital carotid arteries: imaging the relationship between collagen and inflammatory cells in atherosclerotic plaques. J Biomed Opt. 2008;13:044022.

9. Megens RTA, Reitsma S, Prinzen L, oude Egbrink MG, Engels W, Leenders PJ, Brunenberg EJ, Reesink KD, Janssen BJ, ter Haar Romeny BM, Slaaf DW, van Zandvoort MA. In vivo high-resolution structural imaging of large arteries in small rodents using two-photon laser scanning microscopy. J Biomed Opt. 2010;15:011108.

10. van Triest HJ, Megens RTA, van Assen HC, ter Haar Romeny BM, van Zandvoort MA. Arterial radius estimation from microscopic data using a new algorithm for circle parameter estimation.  J Biomed Opt. 2010;15:026012.

11. Subramanian P, Karshovska E, Reinhard P, Megens RTA, Zhou Z, Akhtar S, Schumann U, Li X, van Zandvoort M, Ludin C, Weber C, Schober A. Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation. Circ Res. 2010;107:96-105.

12. Drechsler M, Megens RTA, van Zandvoort MAMJ, Weber C, Soehnlein O. Neutrophils promote atherogenesis in mice. Circulation. 2010;122:1837-45.

13. Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E, Megens RTA, Heyll K, Chun J, Saulnier-Blache JS, Reinholz M, van Zandvoort MAMJ, Weber C, and Schober A. Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium. Cell Metab. 2011;13:592-600.

14. Weber C, Meiler S, Döring Y, Koch M, Drechsler M, Megens RTA, Rowinska Z, Bidzhekov K, Fecher C, Ribechini E, van Zandvoort MA, Binder CJ, Jelinek I, Hristov M, Boon L, Jung S, Korn T, Lutz MB, Förster I, Zenke M, Hieronymus T, Junt T, Zernecke A. CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice. J Clin Invest. 2011;121:2898–2910.

15. Reitsma S, oude Egbrink MGA, Heijnen VVTH, Megens RTA, Engels W, Vink H, Slaaf DW, van Zandvoort MAMJ. Endothelial glycocalyx thickness and platelet-vessel wall interactions during Atherogenesis. Thromb Haemost.2011;106:939-46.

16. Soehnlein LO, Wantha S, Simsekyilmaz S , Doering Y, Megens RTA, Mause SF, Drechsler M, Smeetz R, Weinandy S, Schreiber F, Gries T, Vijayan S, van Zandvoort MAMJ, Agerberth B, Pham CT, Gallo RL, Hackeng TM, Liehn EA, Hristov M, Zernecke A, Klee D, Weber C. Neutrophil-derived cathelicidin protects from neointimal hyperplasia. Sci Transl Med. 2011;3:103ra98

17. Kuijpers MJE, Megens RTA, Nikookhesal E, Feijge MAH, oude Egbrink MGA, van Giezen JJJ, Heemskerk JWM. Role of newly formed platelets in thrombus formation after clopidogrel treatment: comparison to the reversible P2Y12 antagonist ticagrelor. Thromb Haemost. 2011; 106:1179-88.

18. Megens RTA, Vijayan S, Lievens D, Doering Y, van Zandvoort MAMJ, Grommes J, Weber C, Soehnlein O. Presence of luminal neutrophil extracellular traps in atherosclerosis. Thromb Haemost 2012; Feb 8;107(3). [Epub ahead of print] .

19. Döring Y, Manthey H, Drechsler M, Lievens D, Megens RTA, Soehnlein O, Busch M, Manca M, Koenen RR, Pelisek J,  Daemen MJ, Lutgens E, Zenke M,  Binder CJ, Weber C, Zernecke A. Auto-antigenic protein-DNA complexes stimulate plasmacytoid dendritic cells to promote atherosclerosis. Circulation 2012;125:1673-83.

20. Wantha S, Alard JE, Megens RTA, van der Does AM, Döring Y, Drechsler M, Pham CTM, Wang MW, Wang JM, Gallo RL, von Hundelshausen P, Lindbom L, Hackeng T, Weber C, Soehnlein O. Neutrophil-Derived Cathelicidin Promotes Adhesion of Classical Monocytes. Circ Res. 2013; 112(5):792-801.

21. Kramp BK, Megens RTA, Sarabi A, Winkler S, Projahn D, Weber C, Koenen RR, von Hundelshausen P. Exchange of extracellular domains of CCR1 and CCR5 reveals confined functions in CCL5-mediated cell recruitment. Thromb Haemost. 2013;110(4):795-806.

22. Schmitt MMN, Megens RTA, Zernecke A, Bidzhekov K, van den Akker MN, Rademakers T, van Zandvoort MAMJ, Hackeng TM, Koenen RR, Weber C. Endothelial JAM-A guides monocytes into flow-dependent predilection sites of atherosclerosis. Circulation 201;129(1):66-76.

23. Campos DFD, Vogt M, Lindner M, Kirsten A, Weber M, Megens RTA, Pyta J, Zenke M, Zandvoort MA, Fischer H. Two-photon laser scanning microscopy as a useful tool for imaging and evaluating macrophage-, IL-4 activated  macrophage- and osteoclast-based in vitro degradation of beta-tricalcium phosphate bone substitute material. Microsc Res Tech 2014;77(2):143-52.

24. Chèvre R, González-Granado JM*, Megens RTA*, Sreeramkumar V, Silvestre-Roig C, Molina-Sanchez P, Weber C, Soehnlein O, Hidalgo A^+, Andrés V⁺. High-Resolution Imaging of Intravascular Atherogenic Inflammation in Live Mice. Circ Res. 2014;114(5):770-9. (* and ⁺ equal contribution).

25. Döring Y, Noels H, Mandl M, Kramp B, Neideck C, Lievens D, Drechsler M, Megens RTA, Tilstam PV, Langer M, Hartwig H, Theelen W, Marth JD, Sperandio M, Soehnlein O, Weber C. Deficiency of the sialyltransferase St3Gal4 reduces Ccl5-mediated myeloid cell recruitment and arrest. Circ. Res. 2014;114(6):976-81.

26. Schober A*, Nazari.Jahantigh M*, Wei Y, Zhe Z, Gremse F, Grommes J, Megens RTA, Heyll K, Thiemann A, Iruela-Arispe ML, Wang S, Kiessling F, Olson EN, Weber C. An endothelial microRNA controls flow-dependent susceptibility to atherosclerosis. Nat. Med. 2014;Apr;20(4):368-76.

27. Aoqui C, Chmielewski S, Scherer E, Eissler R, Sollinger D, Heid I, Braren R, Schmaderer C, Megens RTA, Weber C, Heemann U, Tschoep M, Baumann M. Microvascular dysfunction in the course of metabolic syndrome induced by high-fat diet. Cardiovasc. Diabetol.2014;3;13:31

28. Karshovska E, ZhaoZ, Blanchet X, Schmitt MNN, Bidzhekov K, Soehnlein O, von Hundelshausen P, Mattheij NJ, Cosemans JMEM, Megens RTA, Koeppel TA, Schober A, Hackeng TM, Weber C and Koenen RR. Hyperreactivity of Junctional Adhesion Molecule A–Deficient Platelets Accelerates Atherosclerosis in Hyperlipidemic Mice. Circ Res. 2014; Published online before print December 3.

Reviews and editorials:

29. Megens RTA, Kemmerich K, Pyta J, Weber C, Soehnlein O. Intravital imaging of phagocyte recruitment. Thromb Haemost. 2011;105(5):802-10.

30. Megens RTA, Soehnlein O.Seeing is believing: an update on modalities to image inflammation in vivo. Thromb Haemost. 2011 May;105(5):774-5.

31. Drechsler M, Döring Y,  Megens RTA,  Soehnlein O. Neutrophilic granulocytes – promiscuous accelerators of atherosclerosis. Thromb Haemost 2011;106: 839–48.

32. Douma K, Megens RTA, van Zandvoort MA. Optical molecular imaging of atherosclerosis using nanoparticles: shedding new light on the darkness. Wiley Interdiscip Rev Nanomed Nanobiotechnol. 2011;3:376-88.