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Vascular Immunotherapy

Myeloid Cells in Vascular Inflammation and Therapy


Atherosclerosis is a chronic inflammatory disorder of large arteries. Following initial endothelial dysfunction, leukocytes start to infiltrate the arterial vessel wall contributing to lumen narrowing and ultimately to plaque rupture clinically evident as myocardial infarction or stroke. Bone marrow- and spleen-derived myeloid cells such as monocytes and neutrophils are crucially involved in atherogenesis, atheroprogression, and atherothrombosis. Our group focuses on recruitment of monocyte subsets and neutrophils to large arteries and on the investigation of pro-atherogenic mechanisms promoted by these cell types. 

The lab of Vascular Immune Therapy is headed by Prof. Dr.Dr. Oliver Söhnlein. 


Current themes:

Mechanisms of hypercholesterolemia-induced changes in leukocyte homeostasis

Functional responses of neutrophils in atherosclerosis

Damage-associated molecular patterns (DAMPs) during early processes of atherosclerosis

Mechanisms underlying neutrophil-mediated monocyte recruitment in atherosclerosis


Jobs in this field  


Prinicpal Investigator:

Prof. Dr. Dr. med. Oliver Söhnlein


Direktor: Prof. Dr. med. Christian Weber

Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten (IPEK)


Pettenkoferstraße 8a & 9

80336 München


Tel.: 089-4400-54351

Fax: 089-4400-54352