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Pathobiochemistry

The lab of Clinical Pathobiochemistry is headed by Prof. Steffens and focuses on two main topics:

 

  • Lipid signaling in cardiovascular disease (PI Steffens)

  • G-protein-coupled receptor signaling (PI Faussner)

 

Lipid signaling in cardiovascular disease

The endocannabinoid system has recently evolved as an endogenous lipid signaling system that is activated in a multitude of disorders, including atherosclerosis. This system comprises at least two distinct membrane receptors, CB1 and CB2, their endogenous ligands (named endocannabinoids) as well as enzymes for ligand biosynthesis and inactivation. Tissue and circulating levels of endocannabinoids and fatty acid amide analogues are dysregulated in atherosclerosis and its related cardiovascular risk factors, obesity, dyslipidemia, diabetes and endothelial dysfunction. However, the pathophysiological effect of this dysregulated tone in cardiovascular disease is not well understood. Our group aims to clarify the precise pathophysiological relevance of its receptors and ligands in cardiovascular disease.

Team:

 Gruppenbild_Steffens_skaliertV3 

Current projects in the lab

Endocannabinoids and related N-acylethanolamines in the pathophysiology of atherosclerosis

Link between endocannabinoid levels and leukocyte recruitment in acute and chronic inflammation

Peripheral functions of other neuromodulators in acute and chronic inflammation

Molecular pathways of cannabinoid receptor signaling

 

Principal investigator

Univ.-Prof. Dr. rer. nat. Sabine Steffens

 

 

 

 

 
 
IPEKlogo

Direktor: Prof. Dr. med. Christian Weber

Institut für Prophylaxe und Epidemiologie der Kreislaufkrankheiten (IPEK)

 

Pettenkoferstraße 8a & 9

80336 München

 

Tel.: 089-4400-54351

Fax: 089-4400-54352

Mail: Kreislaufinstitut@med.uni-muenchen.de

 

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