Publikationen

Hartmann P, Zhou Z, Natarelli L, Wei Y, Nazari-Jahantigh M, Zhu M, Grommes J, Steffens S, Weber C, Schober A. Endothelial Dicer promotes atherosclerosis and vascular inflammation by miRNA-103-mediated suppression of KLF4. Nat Commun. 2016; Feb 3;7:10521. Pubmed

Schober A, Nazari-Jahantigh M, Weber C. Micro-RNA-mediated mechanisms of the cellular stress response in atherosclerosis. Epub 2015 Dec 3. Pubmed

Akhtar S, Hartmann P, Karshovska E, Rinderknecht FA, Subramanian P, Gremse F, Grommes J, Jacobs M, Kiessling F, Weber C, Steffens S, Schober A. Endothelial Hypoxia-inducible Factor-1α promotes atherosclerosis and monocyte recruitment by upregulating MicroRNA-19a. Hypertension. 2015;66(6):1220-6. Pubmed

Hartmann P, Schober A, Weber C. Chemokines and microRNAs in atherosclerosis. Cell Mol Life Sci. 2015; 72(17):3253-66. Pubmed

Schober A, Nazari-Jahantigh M, Weber C. MicroRNA-mediated mechanisms of the cellular stress response in atherosclerosis. Nat Rev Cardiol. 2015;12(6):361-74. Pubmed

Wei Y, Zhu M, Corbalan-Campos J, Heyll K, Weber C, Schober A. Regulation of Csf1r anc Bcl6 in macrophages mediates the Stage-Specific Effects of MicroRNA-155 on Atherosclerosis. Arterioscler Thromb Vasc Biol. 2015;35:796-803. Pubmed

Alampour-Rajabi S, El Bounkari O, Rot A, Muller-Newen G, Bachelerie F, Gawaz M, Weber C, Schober A and Bernhagen J. MIF interacts with CXCR7 to promote receptor internalization, ERK 1/2 and ZAP-70 signaling, and lymphocyte chemotaxis. FASEB J. 2015;29(11):4497-511. Pubmed

Njock MS, Cheng HS, Dang LT, Nazari-Jahantigh M, Lau AC, Boudreau E, Roufaiel M, Cybulsky MI, Schober A and Fish JE. Endothelial cells suppress monocyte activation through secretion of extracellular vesicles containing antiinflammatory microRNAs. Blood 2015; 125:3202-12. Pubmed

Karshovska E, Zhao Z, Blanchet X, Schmitt MM, Bidzhekov K, Soehnlein O, von Hundelshausen P, Mattheij NJ, Cosemans JM, Megens RT, Koeppel TA, Schober A, Hackeng TM, Weber C, Koenen RR. Hyperreactivity of junctional adhesion molecule a-deficient platelets accelerates atherosclerosis in hyperlipidemic mice. Circ Res. 2015;116:587-599. Pubmed

Schober A, Nazari-Jahantigh M, Wei Y, Bidzhekov K, Gremse F, Grommes J, Megens RT, Heyll K, Noels H, Hristov M, Wang S, Kiessling F, Olson EN and Weber C. MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nat Med. 2014;20:368-78. Pubmed

Li X, Zhu M, Penfold ME, Koenen RR, Thiemann A, Heyll K, Akhtar S, Koyadan S, Wu Z, Gremse F, Kiessling F, von Zandervoort M, Schall TJ, Weber C and Schober A. Activation of CXCR7 limits atherosclerosis and improves hyperlipidemia by increasing cholesterol uptake in adipose tissue. Circulation.2014;129:1244-53. Pubmed

Bang C, Batkai S, Dangwal S, Gupta SK, Foinquinos A, Holzmann A, Just A, Remke J, Zimmer K, Zeug A, Ponimaskin E, Schmiedl A, Yin X, Mayr M, Halder R, Fischer A, Engelhardt S, Wei Y, Schober A, Fiedler J and Thum T. Cardiac ficroblast-derived microRNA passenger strand-enriched exosomes mediate cardiomyocyte hapertrophy. J Clin Invest. 2014;124:2136-46. Pubmed

Noels H, Zhou B, Tilstam PV, Theelen W, Li X, Pawig L, Schmitz C, Akhtar S, Simsekyilmaz S, Shagdarsuren E, Schober A, Adams RH, Bernhagen J, Liehn EA, Doring Y and Weber C. Deficiency of endothelial CXCR4 reduces reendothelialization and enhances neointimal hyperplasie after vascular injury in atherosclerosis-prone mice. Atheroiscler Thromb Vasc Biol. 2014;34:1209-20. Pubmed

Vijayan S, Asare Y, Grommes J, Soehnlein O, Lutgens E, Shagdarsuren G, Togtokh A, Jacobs MJ, Fischer JW, Bernhagen J, Weber C, Schober A and Shagdasuren E. High expresseion of C5L2 correlates with high proinflammatory cytokine expression in advances human atherosclerotic plaques. Am J Pathol. 2014;184-2123-33. Pubmed

Neth P, Nazari-Jahantigh M, Schober A, Weber C. MicroRNAs in flow-dependent vascular remodelling. Cardiovasc Res. 2013 May 13. Pubmed 

Wei Y, Nazari-Jahantigh M, Chan L, Zhu M, Heyll K, Corbalán-Campos J, Hartmann P, Thiemann A, Weber C, Schober A. The microRNA-342-5p fosters inflammatory macrophage activation through an Akt1- and microRNA-155-dependent pathway during atherosclerosis. Circulation. 2013; Apr 16;127(15):1609-19. Pubmed

Wei Y, Nazari-Jahantigh M, Neth P, Weber C, Schober A. MicroRNA-126, -145, and -155: a therapeutic triad in atherosclerosis? Arterioscler Thromb Vasc Biol. 2013;33:449-454. Pubmed

Kanzler I, Tuchscheerer N, Steffens G, Simsekyilmaz S, Konschalla S, Kroh A, Simons D, Asare Y, Schober A, Bucala R, Weber C, Bernhagen J, Liehn EA. Differential roles of angiogenic chemokines in endothelial progenitor cell-induced angiogenesis. Basic Res Cardiol. 2013;108. Pubmed

Akhtar S, Gremse F, Kiessling F, Weber C, Schober A. CXCL12 promotes the stabilization of atherosclerotic lesions mediated by smooth muscle progenitor cells in Apoe-deficient mice. Arterioscler Thromb Vasc Biol. 2013;33:679-686. Pubmed

Schuh A, Kroh A, Konschalla S, Liehn EA, Sobota RM, Al Biessen E, Bot I, Taha ST, Schober A, Marx N, Weber C, Sasse A. Myocardial regeneration by transplantation of modified endothelial progenitor cells expressing SDF-1 in a rat model. J Cell Mol Med. 2012;16:2311-2320. Pubmed

Schober A, Thum T, Zernecke A. MicroRNAs in vascular biology - metabolism and atherosclerosis. Thromb Haemost. 2012;107:603-604. Pubmed

Schober A, Siess W. Lysophosphatidic acid in atherosclerotic diseases. Br J Pharmacol. 2012;167:465-482. Pubmed

Nazari-Jahantigh M, Wei Y, Schober A. The role of microRNAs in arterial remodelling. Thromb Haemost. 2012;107:611-618. Pubmed

Nazari-Jahantigh M, Wei Y, Noels H, Akhtar S, Zhou Z, Koenen RR, Heyll K, Gremse F, Kiessling F, Grommes J, Weber C, Schober A. MicroRNA-155 promotes atherosclerosis by repressing Bcl6 in macrophages. J Clin Invest. 2012;122:4190-4202. Pubmed

Hamesch K, Subramanian P, Li X, Dembowsky K, Chevalier E, Weber C, Schober A. The CXCR4 antagonist POL5551 is equally effective as sirolimus in reducing neointima formation without impairing re-endothelialisation. Thromb Haemost. 2012;107:356-368. Pubmed

Egea V, Schober A, Weber C. Circulating miRNAs: messengers on the move in cardiovascular disease. Thromb Haemost. 2012;108:590-591. Pubmed

Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E, Megens R, Heyll K, Chun J, Saulnier-Blache JS, Reinholz M, van Zandvoort M, Weber C, Schober A. Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metab. 2011;13:592-600. Pubmed

Schober A, Weber C. Bone marrow-derived smooth muscle cells are breaking bad in atherogenesis. Arterioscler Thromb Vasc Biol. 2011;31:1258-1259. Pubmed

Schober A, Hristov M, Kofler S, Forbrig R, Loehr B, Heussen N, Zhe Z, Akhtar S, Schumann U, Kroetz F, Leibig M, Koenig A, Kaczmarek I, Reichart B, Klauss V, Weber C, Sohn H-Y. CD34(+)CD140b(+) cells and circulating CXCL12 correlate with the angiographically assessed severity of cardiac allograft vasculopathy. Eur Heart J. 2011;32:476-484. Pubmed

Liehn EA, Tuchscheerer N, Kanzler I, Drechsler M, Fraemohs L, Schuh A, Koenen RR, Zander S, Soehnlein O, Hristov M, Grigorescu G, Urs AO, Leabu M, Bucur I, Merx MW, Zernecke A, Ehling J, Gremse F, Lammers T, Kiessling F, Bernhagen J, Schober A, Weber C. Double-edged role of the CXCL12/CXCR4 axis in experimental myocardial infarction. J Am Coll Cardiol. 2011;58:2415-2423. Pubmed

Gremse F, Grouls C, Palmowski M, Lammers T, de Vries A, Grull H, Das M, Muhlenbruch G, Akhtar S, Schober A, Kiessling F. Virtual elastic sphere processing enables reproducible quantification of vessel stenosis at CT and MR angiography. Radiology. 2011;260:709-717. Pubmed

Weber C, Schober A, Zernecke A. MicroRNAs in arterial remodelling, inflammation and atherosclerosis. Curr Drug Targets. 2010;11:950-956. Pubmed

Subramanian P, Schober A. Neointima formation after vascular injury: Is it all about CD39? Thromb Haemost. 2010;103:257-258. Pubmed

Subramanian P, Karshovska E, Reinhard P, Megens RT, Zhou Z, Akhtar S, Schumann U, Li X, van Zandvoort M, Ludin C, Weber C, Schober A. Lysophosphatidic acid receptors LPA1 and LPA3 promote CXCL12-mediated smooth muscle progenitor cell recruitment in neointima formation. Circ Res. 2010;107:96-105. Pubmed

Lievens D, Gerdes N, Schober A, Weber C. Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol. 2010;21:284-285. Pubmed

Zernecke A, Bidzhekov K, Noels H, Shagdarsuren E, Gan L, Denecke B, Hristov M, Koppel T, Jahantigh MN, Lutgens E, Wang S, Olson EN, Schober A, Weber C. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Sci Signal. 2009;2:ra81. Pubmed

Zernecke A, Bot I, Djalali-Talab Y, Shagdarsuren E, Bidzhekov K, Meiler S, Krohn R, Schober A, Sperandio M, Soehnlein O, Bornemann J, Tacke F, Biessen EA, Weber C. Protective role of CXC receptor 4/CXC ligand 12 unveils the importance of neutrophils in atherosclerosis. Circ Res. 2008;102:209-217. Pubmed

Schober A, Weber C. Leptin and EPCs in arterial injury: yes, we can! Circ Res. 2008;103:447-449. Pubmed

Schober A, Bernhagen J, Weber C. Chemokine-like functions of MIF in atherosclerosis. J Mol Med. 2008;86:761-770. Pubmed

Karshovska E, Zagorac D, Zernecke A, Weber C, Schober A. A small molecule CXCR4 antagonist inhibits neointima formation and smooth muscle progenitor cell mobilization after arterial injury. J Thromb Haemost. 2008;6:1812-1815. Pubmed

Hristov M, Zernecke A, Schober A, Weber C. Adult progenitor cells in vascular remodeling during atherosclerosis. Biol Chem. 2008;389:837-844. Pubmed

Schober A, Zernecke A. Chemokines in vascular remodeling. Thromb Haemost. 2007;97:730-737. Pubmed

Nowak B, Weber C, Schober A, Zeiffer U, Liehn EA, von Hundelshausen P, Reinartz P, Schaefer WM, Buell U. Indium-111 oxine labelling affects the cellular integrity of haematopoietic progenitor cells. Eur J Nucl Med Mol Imaging. 2007;34:715-721. Pubmed

Karshovska E, Zernecke A, Sevilmis G, Millet A, Hristov M, Cohen CD, Schmid H, Krotz F, Sohn H-Y, Klauss V, Weber C, Schober A. Expression of HIF-1 alpha in injured arteries controls SDF-1 alpha-Mediated neointima formation in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol. 2007;27:2540-2547. Pubmed

Bernhagen J, Krohn R, Lue H, Gregory JL, Zernecke A, Koenen RR, Dewor M, Georgiev I, Schober A, Leng L, Kooistra T, Fingerle-Rowson G, Ghezzi P, Kleemann R, McColl SR, Bucala R, Hickey MJ, Weber C. MIF is a noncognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nat Med. 2007;13:587-596. Pubmed

Schober A, Karshovska E, Zernecke A, Weber C. SDF-1 alpha-Mediated tissue repair by stem cells: A promising tool in cardiovascular medicine? Trends in Cardiovascular Medicine. 2006;16:103-108. Pubmed

Hristov M, Heussen N, Schober A, Weber C. Intracoronary infusion of autologous bone marrow cells and left ventricular function after acute myocardial infarction: a meta-analysis. J Cell Mol Med. 2006;10:727-733. Pubmed

Burger-Kentischer A, Gobel H, Kleemann R, Zerneckee A, Bucala R, Leng L, Finkelmeier D, Geiger G, Schaefer H, Schober A, Weber C, Brunner H, Rutten H, Ihling C, Bernhagen J. Reduction of the aortic inflammatory response in spontaneous atherosclerosis by blockade of macrophage migration inhibitory factor (MIF). Atherosclerosis. 2006;184:28-38. Pubmed

Zernecke A, Schober A, Bot I, von Hundelshausen P, Liehn E, Mopps B, Mericskay M, Gierschik P, Biessen E, Weber C. SDF-1 alpha/CXCR4 axis is instrumental in neointimal hyperplasia and recruitment of smooth muscle progenitor cells. Circ Res. 2005;96:784-791. Pubmed

Schober A, Weber C. Mechanisms of monocyte recruitment in vascular repair after injury. Antioxid Redox Signal. 2005;7:1249-1257. Pubmed

Schober A, Hoffmann R, Opree N, Knarren S, Iofina E, Hutschenreuter G, Hanrath P, Weber C. Peripheral CD34+ cells and the risk of in-stent restenosis in patients with coronary heart disease. Am J Cardiol. 2005;96:1116-1122. Pubmed

Ostermann G, Fraemohs L, Baltus T, Schober A, Lietz M, Zernecke A, Liehn E, Weber C. Involvement of JAM-A in mononuclear cell recruitment on inflamed or atherosclerotic endothelium - Inhibition by soluble JAM-A. Arterioscler Thromb Vasc Biol. 2005;25:729-735. Pubmed

Furnkranz A, Schober A, Bochkov V, Bashtrykov P, Kronke G, Kadl A, Binder B, Weber C, Leitinger N. Oxidized phospholipids trigger atherogenic inflammation in murine arteries. Arterioscler Thromb Vasc Biol. 2005;25:633-638. Pubmed