We investigate the contribution of non-coding RNAs (ncRNAs) in cardiovascular physiology and pathology. We are particularly interested in mechanisms of regulation, trafficking, and function of ncRNAs in the maintenance of vascular homeostasis and their involvement in the development of vascular diseases, such as atherosclerosis. Our goal is to shed light on the relevance of ncRNAs in the development of vascular disease and to unveil their possible application as therapeutic or diagnostic/prognostic tools in patients with cardiovascular diseases.