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Protective signal pathways identified

04.05.2017 -

Atherosclerosis is characterized by the build-up of fat-rich deposits on the inner surfaces of the endothelial cells that form the walls of the blood vessels. The presence of these atherosclerotic “plaques” leads to a chronic inflammation reaction, which can ultimately result in constriction of the vessel and the obstruction of blood flow in major arteries. Research teams led by Professor Christian Weber, Director of the Institute for Prophylaxis and Epidemiology of Cardiovascular Diseases (IPEK) at the LMU Medical Center, have long focused their efforts on understanding the molecular mechanisms that underlie the pathogenesis and progression of the disorder. In two new studies, which appear in the journal Circulation, he and his colleagues now describe two previously unknown mechanisms that help to retard the formation of atherosclerotic plaques. Read further: