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Klinische Massenspektrometrie / Clinical Mass Spectrometry

Leitung:

Bild: mvogeser

Prof. Dr. med. Michael Vogeser

+49 89 4400-73221

 

Arbeitsgruppe:

Bild: mpaal

Dr. med. univ. Dr. rer. nat. Michael Paal, PhD

+49 89 4400-73200

jolindne

Johanna Lindner (Pharmazeutin)

+49 89 4400-73119

cschuste

Carina Schuster (Pharmazeutin)

+49 89 4400-76107

rlang

Robert Lang (Pharmazeut)

+49 89 885660-16116

ksorg

Katharina Sorg (CTA)

+49 89 4400-73119

Anne Schliemann (cand. med.)

Philipp Schmoeckel (cand. med.)

  • Scientific Analytics and Translational Diagnostics: Development of mass spectrometry based methods for use in clinical diagnostic testing
  • Therapeutic drug monitoring of antibiotics in intensive care medicine
  • Endocrinological profilling methods
  • Automation and integration in clinical application of mass spectrometry, Private-Public-Partnership projects
  • Quality and risk management in clinical applications of mass spectrometry
  • Prof. Vogeser is Co-Editor-in-Chief of the Elsevier journal Clinical Mass Spectrometry

 

Selected publications

Vogeser M, Seger C. Mass spectrometry methods in clinical diagnostics – state of the art and perspectives. Trends in Analytical Chemistry 2016

Vogeser M, Seger C. Quality management in clinical application of mass spectrometry measurement systems. Clin Biochem. 2016 Sep;49(13-14):947-54.

Lucha S, Taibon J, Pongratz S, Geletneky C, Huber E, Wintterle-Roehm C, Lang R, Grimm SH, Duelffer T, Tarasov K, Zander J, Vogeser M, Kobold U. An LC-MS/MS based candidate reference method for the quantification of total gentamicin in human serum and plasma using NMR characterized calibrator material. Clin Chim Acta. 2016 Nov 19;464:211-217.

Suhr AC, Bruegel M, Maier B, Holdt LM, Kleinhempel A, Teupser D, Grimm SH, Vogeser M. Ferromagnetic particles as a rapid and robust sample preparation for the absolute quantification of seven eicosanoids in human plasma by UHPLC-MS/MS. J Chromatogr B Analyt Technol Biomed Life Sci 2016

Zander J, Maier B, Zoller M, Teupser D, Vogeser M. Quantification of linezolid in serum by LC-MS/MS using semi-automated sample preparation and isotope dilution internal standardization. Clin Chem Lab Med 2013

Baecher S, Geyer R, Lehmann C, Vogeser M. Absorptive chemistry based extraction for LC-MS/MS analysis of small molecule analytes from biological fluids - an application for 25-hydroxyvitamin D. Clin Chem Lab Med 2013

König K, Kobold U, Fink G, Leinenbach A, Dülffer T, Thiele R, Zander J, Vogeser M. Quantification of vancomycin in human serum by LC-MS/MS. Clin Chem Lab Med 2013

König K, Goethel SF, Rusu VM, Vogeser M. Deproteination of serum samples for LC-MS/MS analyses by applying magnetic micro-particles. Clin Biochem 2013

Vogeser M, Kirchhoff F, Geyer R. A novel approach to signal normalisation in atmospheric pressure ionisation mass spectrometry. J Pharmaceut Biomed Anal J Pharm Biomed Anal 2012

Kirchhoff F, Briegel J, Vogeser M. Quantification of free serum cortisol based on equilibrium dialysis and isotope dilution-liquid chromatography-tandem mass spectrometry. Clin Biochem 2011

Vogeser M, Seger C. Pitfalls associated with the use of liquid chromatography-tandem mass spectrometry (LC-MS/MS) in the clinical laboratory. Clin Chem 2010