CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing.
23.05.2016 - We analyzed the immunopathology of Rasmussen encephalitis, a rare pediatric epilepsy, by deep sequencing of T cell receptor chains. We identified public T cell clones, i.e. clones that are shared between different patients. This suggests that antigen-driven T cell expansions are a major cause of the lymphocyte attack against brain tissue. [more...]