Our Lab

Spinal Cord Repair

Welcome to the lab of Florence Bareyre, PhD

 

ag_bareyre_gruppenfoto

Group photo

 

Our Aim

Traumatic, ischemic and inflammatory lesions to the spinal cord lead to the transection of descending and ascending axonal tract systems. If these lesions are complete – i.e. if all axons in the spinal cord are transected – severe and persistent functional deficits ensue. If however the lesions are incomplete and some axonal tracts are spared, some recovery of function can be observed. We are studying the anatomical, functional and molecular mechanisms underlying the recovery process in an attempt to develop new therapeutic strategies that can support spinal cord repair in neurological disease caused by trauma, ischemia or inflammation.

 

Our Approach

Over the recent years we have used the rodent corticospinal tract – a major descending motor pathway – to study how axonal connections remodel in response to injury. We could identify the de novo formation of intraspinal detour circuits as a key remodelling process that mediates recovery of function. We are currently using (i) anterograde, retrograde and trans-synaptic tracing techniques in combination with confocal microscopy to reveal the anatomy of spinal detour circuits, (ii) genetic and pharmacological manipulations to dissect the molecular interactions that regulate detour circuit formation and (iii) electrophysiological recordings and behavioural testing to assess effects on functional recovery.

 

Our Support

Our research group is supported by an independent group leader award from the German Federal Ministry for Research and Education (BMBF). We are further part of several research consortia funded by the German National Science Foundation (DFG) ) including the Excellence Cluster “SyNergy – Munich Cluster for Systems Neurology“, the  Collaborative Research Centres 870 („Assembly and function of neuronal circuits in sensory processing”)and the Graduate School of Systemic Neurosciences (GSNLMU) as well as the Munich Center for Neurosciences (MCNLMU).

 

 
DE

Director

Prof. Dr.

Reinhard Hohlfeld

Contact  


Prof. Dr.

Martin Kerschensteiner

Contact  

Group Leader

Dr.

Florence Bareyre

Contact 

Important links