Press

Ann Neurol 2018;84:315–328

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

01.10.2018 - Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) can be detected in the blood of a proportion of patients with inflammatory demyelinating diseases of the CNS. We affinity-purified MOG-Abs from the blood of two patients. The Abs recognized different epitopes on MOG. The anti-MOG Abs from the patients were pathogenic upon transfer into rats and we could dissect two different mechanisms by which these MOG-Abs enhanced pathology. First, together with cognate MOG-specific T cells, these Abs enhanced T cell infiltration; Second, together with MBP-specific T cells that strongly breach the blood-brain barrier, these MOG-Abs induced demyelination associated with deposition of C9neo, resembling a multiple sclerosis type II pathology. This suggests that MOG-Abs are similarly pathogenic in patients. [more...]

 
Nature Neuroscience 21:1196-1208 (2018)

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model.

02.09.2018 - Here we use an in vivo imaging approach to follow the evolution of phagocyte phenotypes in neuroinflammatory lesions. By tracking phagocytes over time we can show that individual phagocytes switch their phenotype as lesions move from expansion to resolution. [more...]

 
J Neurol Neurosurg Psychiatry. 2018 Jun 19. pii: jnnp-2018-318382. doi: 10.1136/jnnp-2018-318382

Retinal ganglion cell loss in neuromyelitis optica: a longitudinal study

22.06.2018 - Neuromyelitis optica spectrum disorders (NMOSD) are inflammatory conditions of the central nervous system and an important differential diagnosis of multiple sclerosis (MS). Unlike MS, the course is usually relapsing, and it is unclear, if progressive neurodegeneration contributes to disability. T... [more...]

 
Interessierte Zwillinge können jederzeit noch in die Studie eingeschlossen werden!

Deutschlandweite MS-Zwillings-Studie-Teilnehmer gesucht

21.04.2018 - Aktuell suchen wir insbesondere dringend eineiige Zwillingspaare bei denen beide Zwillinge an Multipler Sklerose erkrankt ist. [more...]

 
open position: PhD student

The Meinl lab is looking for a PhD candidate

10.12.2017 - We are looking for a PhD candidates. For more details see attached documents: [more...]

 
Press release

Twin study suggests that human gut bacteria (microbiota) can trigger multiple sclerosis (MS).

12.09.2017 - MS is presumably an autoimmune disorder, but the triggers of the autoimmune reaction have remained unknown. A new study showed that microbiota from MS patients can induce MS-like disease in an animal model. [more...]

 
Proc Natl Acad Sci U S A. 2017 Jul 17. pii: 201701806. doi: 10.1073/pnas.1701806114. [Epub ahead of print]

Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy

04.08.2017 - Here we visualized intracellular calcium in the encephalitogenic T cells in vivo by using FRET based sensor. The T cells showed short and long lasting calcium signaling dependent on their interaction partners. The blocking of the calcium signaling can be used as target of therapeutic treatments. [more...]

 
Presseerklärung

DMSG Forschungsprojekte zur Progredienten Multiplen Sklerose

04.12.2016 - Dr. Mehrnoosh Jafari und Prof. Martin Kerschensteiner wollen verstehen, wie es bei der Progredienten Verlaufsform der Multiplen Sklerose zum Nervenzellschaden kommt. Dieses Forschungsvorhaben wird jetzt von der Deutschen Multiple Sklerose Gesellschaft gefördert. [more...]

 
Dtsch Arztebl Int 2016; 113(51-52): 879-86; DOI: 10.3238/arztebl.2016.0879

Interdisciplinary Risk Management in the Treatment of Multiple Sclerosis

03.12.2016 - The growing number of drugs used to treat MS demands great efforts to minimize the potential risks. To this end, interdisciplinary risk management plans are essential. Here we describe the type and extent of risks, the measures needed for prevention/early detection, and provide practical advice f... [more...]

 
Nat Commun. 2016 Nov 16;7:13275. doi: 10.1038/ncomms13275.

Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model.

02.12.2016 - Here we investigate how oligodendrocyte damage is initiated in multiple sclerosis (MS) and EAE. We can show that oligodendrocyte damage spreads centripetally and that the formation of focal myelin outfoldings that we call “myelinosomes” is an early sign of oligodendrocyte damage both in MS and EAE. [more...]

 
open position: PostDoc and PhD

The Liebscher lab is looking for a postdoctoral researcher and a PhD candidate

13.10.2016 - We are looking for postdoctoral researchers and PhD candidates. For more details see attached documents: [more...]

 
open position: PostDoc and PhD

The Kerschensteiner Lab is looking for a postdoctoral researcher and a PhD candidate

14.06.2016 - We are looking for postdoctoral researchers and PhD candidate that are interested in studying the in vivo pathogenesis of multiple sclerosis in collaborative projects with the Misgeld lab at the Technical University Munich. For more details see attached documents: [more...]

 
Nat Commun. 2016 Apr 4;7:11153. doi: 10.1038/ncomms11153.

CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing.

27.04.2016 - We analyzed the immunopathology of Rasmussen encephalitis, a rare pediatric epilepsy, by deep sequencing of T cell receptor chains. We identified public T cell clones, i.e. clones that are shared between different patients. This suggests that antigen-driven T cell expansions are a major cause of t... [more...]

 
Brain 2016: 139; 1312–1324 DOI: http://dx.doi.org/10.1093/brain/aww053 . [Epub ahead of print]

Cytotoxic T cells go awry in inclusion body myositis

26.04.2016 - [more...]

 
JAMA Neurol. 2016 Apr 4. doi: 10.1001/jamaneurol.2016.0259. [Epub ahead of print]

Alemtuzumab and Multiple Sclerosis: Another Note of Caution.

04.04.2016 - [more...]

 
Lancet Neurol. 2015 Dec 23. pii: S1474-4422(15)00334-8. doi: 10.1016/S1474-4422(15)00334-8.

The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets

23.12.2015 - Part 1 Identification of the target antigens of adaptive immunity (B cells and T cells) is of fundamental importance for understanding the pathogenesis of multiple sclerosis and for the development of personalized therapies. In part 1 of this two-part Review, we focus on CD4+ T lymphocytes as majo... [more...]

 
J Exp Med. 2015 Dec 14;212(13):2203-12. doi: 10.1084/jem.20151093. Epub 2015 Nov 30.

Melanocyte antigen triggers autoimmunity in human psoriasis

14.12.2015 - Using plasmid-encoded combinatorial peptide libraries (Siewert et al 2012), we identified ADAMTSL5 as a melanocyte autoantigen in human psoriasis. ADAMTSL5 is presented in HLA-C*06:02 molecules on melanocytes, which triggers IL-17 production from CD8+ T cells. [more...]

 
Brain. 2016 Jan;139(Pt 1):39-46. doi: 10.1093/brain/awv353. Epub 2015 Dec 14.

Reconstruction of single cortical projection neurons reveals primary spine loss in multiple sclerosis

14.12.2015 - Here we we use confocal microscopy of Golgi-Cox impregnated tissue sections to reconstruct single cortical projection neurons in brain sections from multiple sclerosis and control patients. Our study reveals a widespread loss and pronounced loss of dendritic spines that occurs independently of cor... [more...]

 
open position: PhD candidate

The Kawakami Lab is looking for PhD candidate for the project

17.09.2015 - Our lab studies the roles of autoreactive T cells during CNS inflammation. [more...]

 
Nat. Commun. 6:7333 doi: 10.1038/ncomms8333

γ-secretase directly sheds the survival receptor BCMA from plasma cells

12.06.2015 - Plasma cells produce antibodies that inactivate pathogens, but may also cause autoimmune diseases. Therefore a balanced regulation of plasma cells is essential. We found that the lifespan of plasma cells is regulated through shedding of their survival receptor BCMA by γ-secretase. The released par... [more...]

 
EMBO J. 2015 Mar 12. pii: e201490578. [Epub ahead of print]

FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord

24.03.2015 - Following spinal cord injury, transected projections form detour circuits that circumvent the lesion and contribute to functional recovery. The formation of new synaptic contacts is a crucial step of the process, but its molecular regulation is currently not understood. Here, we show that: • FGF2... [more...]

 
Neuron 84: 1183-1190 (2014)

Pervasive axonal transport deficits in multiple sclerosis models

06.01.2015 - Here we visualize the dynamics of organelles in individual spinal axons and reveal widespread impairment of organelle transport in MS models. Transport deficits precede structural alterations of axons, myelin or microtubules. They persist in chronic MS models and lead to a reduced distal organel... [more...]

 
Nature Communications 5:5683 doi:10.1038/ncomms6683 (2014)

A recoverable state of axon injury persists for hours after spinal contusion in vivo

06.09.2014 - Here we use spinal in vivo imaging to show that axons persist in a metastable state for hours after spinal contusion injury. During this time the intra-axonal calcium dynamics determine the axonal fate. Those axons that manage to re-establish calcium homoestasis will survive longterm while those t... [more...]

 
First published online: July 23, 2014, Brain (2014) doi: 10.1093/brain/awu205

Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation

07.08.2014 - Oligoclonal bands in the cerebrospinal fluid are the most important immunological marker of multiple sclerosis. Whereas oligoclonal IgG bands were intensely investigated in the past, little is known about intrathecal IgM antibodies. Using state-of-the-art technologies, including deep sequencing an... [more...]

 
Journal of Cell Biology 206, 335-345 (2014)

A unified cell biological perspective on axon-myelin injury

06.08.2014 - Here we review recent advances in our understanding of the mechanisms that mediate axon and myelin injury in neuroinflammatory conditions and propose that the close cell biological interconnection of the axon-myelin unit could help explain the spread of pathology in advanced stages of MS. [more...]

 
Nature Medicine 20, 555-560 (2014)

Multparametric optical analysis of mitochondrial redox signals during neuronal physiology and pathology in vivo

22.05.2014 - Here we establish a novel multiparametric imaging approach that allows us to visualize and mechanistically dissect mitochondrial redox signals with high temporal and spatial resolution in the living nervous system. [more...]

 
Nature. 2013 Oct 9. doi: 10.1038/nature12694

Multiple sclerosis: An old drug plays a new trick

17.10.2013 - In this News & Views article we present an advance towards repair of multiple sclerosis lesions. [more...]

 
EMBO Rep. 2013 Sep 30;14(10):931-7. doi: 10.1038/embor.2013.117

STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury

30.09.2013 - Here we show that viral gene transfer of the transcription factor STAT3 can induce remodeling if unlesioned fibers and thereby improve functional recovery after spinal cord injury. [more...]

 
open position: Post Doc

The Kerschensteiner lab at the Institute of Clinical Neuroimmunology is looking for a Post Doc

23.09.2013 - The Kerschensteiner Lab and the Misgeld Lab at the TUM are looking to fill an open Post Doc position within the SyNergy project. [more...]

 
Nat Rev Neurol. 2013 May;9(5):267-76. doi: 10.1038/nrneurol.2013.41

The utility of cerebrospinal fluid analysis in patients with multiple sclerosis

01.08.2013 - Alterations of the cerebrospinal fluid are commonly found in multiple sclerosis. This review presents the utility of cerebrospinal fluid analysis for diagnosis, its impact on our understanding of the pathophysiology and therapy mechanisms, as well as for monitoring inflammatory and neurodegenerati... [more...]

 
Brain. 2013 Jun;136(Pt 6):1778-82. doi: 10.1093/brain/awt101

MANBA, CXCR5, SOX8, RPS6KB1 and ZBTB46 are genetic risk loci for multiple sclerosis.

15.07.2013 - We tested five single nucleotide polymorphisms rs228614 (MANBA), rs630923 (CXCR5), rs2744148 (SOX8), rs180515 (RPS6KB1), and rs6062314 (ZBTB46) for association with multiple sclerosis risk in a total of 8499 cases with multiple sclerosis, 8765 unrelated control subjects and 958 trios of European d... [more...]

 
open positions: PhD candidates

The Kerschensteiner lab at the Institute of Clinical Neuroimmunology is looking for PhD candidates

08.07.2013 - Our lab studies the mechanisms underlying tissue damage in multiple sclerosis. This PhD project is part of the Collaborative Research Center SFB-Tr128. [more...]

 
Nature Medicine 2013 May 12; doi:10.1038/nm.3180 [Epub ahead of print]

Real-time in vivo analysis of T cell activation in the central nervous system using a genetically encoded calcium indicator

12.05.2013 - Here, we introduce fluorescence resonance energy transfer (FRET) based activation sensor, which can be expressed stably in T cells. Intravital imaging detects the change of intracellular calcium level. [more...]

 
J Clin Invest. 2013;123(3):1192–1201. doi:10.1172/JCI67233

2-photon imaging of phagocyte-mediated T cell activation in the CNS

01.03.2013 - Here, we show T cell activation within the CNS by using NFAT-GFP fusion protein and two-photon intravital microscopy. A part of APCs in the spinal cord leptomeninges present endogenous antigens to infiltrated autoreactive T cells and activate them. [more...]

 
open positions: clinician scientist

Clinician Scientist Group at the Institute of Clinical Neuroimmunology

20.02.2013 - The Clinician-Scientist Program of the DFG-sponsored Excellence Cluster “Munich Cluster for Systems Neurology (SyNergy)” will offer young clinician-scientists the opportunity to efficiently combine residency training. [more...]

 
Nature Protocols 8, 481–490 (2013) doi:10.1038/nprot.2013.022

Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes

07.02.2013 - Here we show how vital dyes can be used to label and image cells, subcellular organelles and effector molecules in the spinal cord of living mice. [more...]

 
Nat Med. 2012 Dec 6;18(12):1743-5

Ion channels boost axonal injury in multiple sclerosis

06.12.2012 - [more...]

 
Nat Rev Neurol. 2012 Oct 9. doi: 10.1038/nrneurol.2012.203

B cells and antibodies in multiple sclerosis pathogenesis and therapy

09.10.2012 - In diesem Übersichtsartikel beschreiben wir wie das Milieu im ZNS von MS Patienten das Überleben von B-Lymphozyten fördert und diskutieren mögliche Zielstrukturen für Autoantikörper von MS Patienten. Therapeutische Strategien, die B-Lymphozyten direkt entfernen oder einen Effekt auf diese Immunzel... [more...]

 
Nat Med. 2012 May;18(5):824-9

Unbiased identification of target antigens of CD8+ T-cells with combinatorial libraries coding for short peptides

08.04.2012 - We describe an unbiased and generally applicable technology to identify the antigens of MHC class-I restricted T cell receptors. [more...]

 
Nat Methods. 2011 Jun 5;8(7):568-70

Near-infrared branding efficiently correlates light and electron microscopy

05.06.2011 - Here, we describe a new technique that uses fiduciary marks set by a 2-photon laser to correlate light and electron microscopic images. [more...]

 
Nature Medicine 2011 Vol. 17 No. 4

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

27.03.2011 - Here, we use in vivo multiphoton imaging to identify a novel form of axonal degeneration that contributes to axon loss in multiple sclerosis and its animal model. [more...]

 

A possible new target for treatment of multiple sclerosis: Damage to susceptible nerve cells can be reversed

27.03.2011 - Multiple sclerosis is a disabling autoimmune disease in which nerve fibers are attacked by the patient’s own immune system. LMU researchers have identified a new mechanism that contributes to nerve fiber damage -- and shown that this damage can be reversed. [more...]

 
 
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Prof. Dr.

Reinhard Hohlfeld

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Prof. Dr.

Martin Kerschensteiner

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