Welcome at the Institute of Clinical Neuroimmunology

Prof. Hohlfeld

Prof. Dr. Hohlfeld

Our institute is devoted to the diagnosis and treatment of neuroimmunological diseases, that is, autoimmune disorders of the nervous system. In autoimmune diseases, the immune system “erroneously” attacks the body´s own tissues. By far the most frequent of these diseases is multiple sclerosis.

The Institute of Clinical Neuroimmunology was founded in 1999. It is the first university institute in Germany focusing on neuroimmunological diseases. [Continue]



Kerschensteiner_Startseite

Prof. Dr. Kerschensteiner


 

Ann Neurol 2018;84:315–328

Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein

01.10.2018 - Autoantibodies against myelin oligodendrocyte glycoprotein (MOG) can be detected in the blood of a proportion of patients with inflammatory demyelinating diseases of the CNS. We affinity-purified MOG-Abs from the blood of two patients. The Abs recognized different epitopes on MOG. The anti-MOG Abs from the patients were pathogenic upon transfer into rats and we could dissect two different mechanisms by which these MOG-Abs enhanced pathology. First, together with cognate MOG-specific T cells, these Abs enhanced T cell infiltration; Second, together with MBP-specific T cells that strongly breach the blood-brain barrier, these MOG-Abs induced demyelination associated with deposition of C9neo, resembling a multiple sclerosis type II pathology. This suggests that MOG-Abs are similarly pathogenic in patients. [more...]

 
Nature Neuroscience 21:1196-1208 (2018)

Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model.

02.09.2018 - Here we use an in vivo imaging approach to follow the evolution of phagocyte phenotypes in neuroinflammatory lesions. By tracking phagocytes over time we can show that individual phagocytes switch their phenotype as lesions move from expansion to resolution. [more...]

 
J Neurol Neurosurg Psychiatry. 2018 Jun 19. pii: jnnp-2018-318382. doi: 10.1136/jnnp-2018-318382

Retinal ganglion cell loss in neuromyelitis optica: a longitudinal study

22.06.2018 - Neuromyelitis optica spectrum disorders (NMOSD) are inflammatory conditions of the central nervous system and an important differential diagnosis of multiple sclerosis (MS). Unlike MS, the course is usually relapsing, and it is unclear, if progressive neurodegeneration contributes to disability. T... [more...]

 

Dr. Ivana Nikić-Spiegel receives prestigous Friedmund Neumann Award of the Ernst Schering Foundation

20.11.2017 - Former institute member, Dr. Ivana Nikić-Spiegel, receives prestigous Friedmund Neumann Award of the Ernst Schering Foundation for her work on inflammatory disease of the nervous system. [more...]

Dr. Anneli Peters receives the junior research award from the Roman, Marga and Mareille Sobek Foundation

13.12.2017 - Dr. Anneli Peters, who has just started an Emmy Noether-group at our Institute, receives the junior research award from the Roman, Marga and Mareille Sobek Foundation for her outstanding research on... [more...]

Deutschlandweite MS-Zwillings-Studie-Teilnehmer gesucht

21.04.2018 - Aktuell suchen wir insbesondere dringend eineiige Zwillingspaare bei denen beide Zwillinge an Multipler Sklerose erkrankt ist. [more...]