Stellenangebote

The Hospital of the University of Munich, Germany, is one of the largest and most competitive university hospitals in Germany and Europe. 47 specialized hospitals, departments and institutions harboring excellent research and education provide patient care at the highest medical level with approximately 10.000 employees.

 

 

Open position for a postdoctoral scientist (F/M)

T cells, autoimmunity, next generation sequencing

 

Pathogenic  T cells  in  Narcolepsy

 

 

Background:

            We are investigating pathogenic T cells in several autoimmune diseases. Particularly interesting is narcolepsy because it has a very strong genetic bias to HLA-DQB1*06:02. As HLA molecules present antigenic peptides to T cells, it is hypothesized that peptides might initiate the autoimmune attack of T cells against neurons specialized in sleep regulation.

            We are part of a consortium of four laboratories from France and Switzerland. Our colleagues have established a large biobank of patients´ samples, which we investigate by transcriptomics, proteomics and cell biological methods. Our lab will analyze expanded T cell clones by next generation sequencing (Illumina) on the bulk and single cell level and express antigen-specific receptors of disease-related clones recombinantly in order to identify their antigen.

           

Methods: (all techniques are established in our lab)

  • T cell receptor repertoire analyses by single cell Illumina-next-generation sequencing.
  • Recombinant receptor expression.
  • Antigen searches and validation.

We are optimistic that this project will reveal new insights into the pathogenesis of narcolepsy and may have a significant impact on early diagnosis and therapy the disease.

 

We seek:

            Applicants should hold or expect a doctoral degree (PhD, MD). Most importantly, he/she should be highly motivated, interested in joining an interdisciplinary team (Coop.), and ideally have some experience in molecular biology. Computer knowledge is appreciated.

 

We offer:

            The position is funded by a BMBF (E-Rare) grant for 2 years. We offer a TV-L E13 position and are planning to start as soon as possible. Our well-equipped labs are at the new Biomedical Center. We encourage applications of women. In case of equal qualification, disabled individuals will be preferentially considered. Presentation costs cannot be reimbursed.

 

Please apply to:          Klaus.Dornmair@med.uni-muenchen.de

                                   Institute for Clinical Neuroimmunology, Biomedical Center and Hospital of the LMU

                                   Großhaderner Str. 9,  82152 Martinsried, room N.B. 03.013

                                   Tel. 089-2180-71664      http://ini.klinikum.uni-muenchen.de/dornmair_lab.


Open position: PhD in Neuroimmunology

 

The Kerschensteiner lab is looking for a:

 

 PhD candidate

 

who is interested in investigating the regulation of phagocyte effector functions in inflammatory disease of the central nervous system such as multiple sclerosis.

 

Background and question:

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system that affects more than 2 million people worldwide. In MS immune cells enter the brain and spinal cord and damage resident CNS cells including neurons and their axons. We have previously shown that mononuclear phagocytes such as macrophages and microglia cells are key effectors of axon and myelin damage in MS models and developed novel tools to track their phenotype and metabolic state in vivo. In the proposed project we now want to use these in vivo imaging tools in combination with genome editing techniques to decipher the metabolic regulation of phagocytes actions during neuroinflammation.

 

We seek:

We are looking for highly motivated, enthusiastic and hard-working applicants, who are fluent in English. The starting date for this position is flexible, but we aim for spring/summer of 2019.

 

We offer:

Funding for this project is secured for 3 years. The project is associated with the DFG-funded Excellence Cluster for Systems Neurology (SyNergy, for more information see http://www.synergy-munich.de) and the supervisor is a faculty member of the Graduate School of Systemic Neurosciences (http://www.gsn.uni-muenchen.de) and the PhD Program Medical Life Science and Technology (http://www.phd.med.tum.de) that offer excellent structured graduation programs.

 

Please apply to:

If you are interested in the position please send a letter of motivation, your CV and the names and contact details of 2 to 3 references to:

 

Prof. Dr. med. Martin Kerschensteiner

Chair, Institute of Clinical Neuroimmunology

Email: Martin.Kerschensteiner@med.uni-muenchen.de

Webpages: http://ini.klinikum.uni-muenchen.de

                  www.bmc.med.uni-muenchen.de

 

Selected recent publications from our group:

Witte et al., Neuron doi:10.1016 (2019)

Locatelli et al., Nature Neuroscience 21:1196-1208 (2018)

Romanelli et al., Nature Communications 7:13275 (2016)

Goldmann et al., Nature Immunology 17:797-805 (2016)

Sorbara et al., Neuron 84, 1183-1190 (2014)

Breckwoldt et al., Nature Medicine 20, 555-560 (2014)

Nikic et al, Nature Medicine 17:495-499 (2011)