Stellenangebote

Open position: PhD in Neuroimmunology

 

The Kerschensteiner lab is looking for a:

 

 PhD candidate

 

who is interested in investigating the regulation of phagocyte effector functions in inflammatory disease of the central nervous system such as multiple sclerosis.

 

Background and question:

Multiple sclerosis (MS) is a common inflammatory disease of the central nervous system that affects more than 2 million people worldwide. In MS immune cells enter the brain and spinal cord and damage resident CNS cells including neurons and their axons. We have previously shown that mononuclear phagocytes such as macrophages and microglia cells are key effectors of axon and myelin damage in MS models and developed novel tools to track their phenotype and metabolic state in vivo. In the proposed project we now want to use these in vivo imaging tools in combination with genome editing techniques to decipher the metabolic regulation of phagocytes actions during neuroinflammation.

 

We seek:

We are looking for highly motivated, enthusiastic and hard-working applicants, who are fluent in English. The starting date for this position is flexible, but we aim for spring/summer of 2019.

 

We offer:

Funding for this project is secured for 3 years. The project is associated with the DFG-funded Excellence Cluster for Systems Neurology (SyNergy, for more information see http://www.synergy-munich.de) and the supervisor is a faculty member of the Graduate School of Systemic Neurosciences (http://www.gsn.uni-muenchen.de) and the PhD Program Medical Life Science and Technology (http://www.phd.med.tum.de) that offer excellent structured graduation programs.

 

Please apply to:

If you are interested in the position please send a letter of motivation, your CV and the names and contact details of 2 to 3 references to:

 

Prof. Dr. med. Martin Kerschensteiner

Chair, Institute of Clinical Neuroimmunology

Email: Martin.Kerschensteiner@med.uni-muenchen.de

Webpages: http://ini.klinikum.uni-muenchen.de

                  www.bmc.med.uni-muenchen.de

 

Selected recent publications from our group:

Witte et al., Neuron doi:10.1016 (2019)

Locatelli et al., Nature Neuroscience 21:1196-1208 (2018)

Romanelli et al., Nature Communications 7:13275 (2016)

Goldmann et al., Nature Immunology 17:797-805 (2016)

Sorbara et al., Neuron 84, 1183-1190 (2014)

Breckwoldt et al., Nature Medicine 20, 555-560 (2014)

Nikic et al, Nature Medicine 17:495-499 (2011)


The Institute of Clinical Neuroimmunology offers a

Master thesis in the Meinl Lab

Topic: Identification of brain-reactive antibodies in Multiple Sclerosis and related diseases

Background and question:
Multiple Sclerosis (MS) is the most common inflammatory demyelinating disease of the central nervous system (CNS) in young adults with a high risk of future disability. An important role of antibodies (Abs) and B cells has emerged only recently and is based on the beneficial therapeutic effects of B cell - targeted treatment in a subgroup of MS patients, the identification of B cells in meningeal lymphoid structures, and antibody and complement deposition in brain lesions of several patients. The ongoing search for novel antigens has been successful in diseases that can closely resemble MS . We aim to understand the prevalence of brain reactive Abs (BRAB) in different MS patients and related disease by establishing high flow throughput assays that also allow us to detect antibodies that require the antigen in a certain configuration. We aim to understand BRAB in MS patients and related diseases by establishing a high flow throughput assay. In addition we aim to identify a novel Antigen(AG) in patients who are positive for BRAB by using a combination of different assays, such as single cell sorting of B cells, analysis of BRAB-AG binding on a large protein array and other techniques. We will investigate the frequency of AG specific BRAB in MS patients, related diseases and controls. This approach might allow personalized treatment of patients, and maybe results in further subdivision of MS into separate disease entities.

Methods: Immunohistochemistry, Western blot, FACS, cell culture and others

Supervision: Dr. Simone Mader and Prof. Dr. Edgar Meinl

Prior experiences in laboratory work are required. Applications comprising of a curriculum vitae and relevant documents should be sent within a single PDF file via email to

Simone.Mader@med.uni-muenchen.de

Institut für Klinische Neuroimmunologie
Biomedizinisches Zentrum und
Klinikum der Ludwig-Maximilians-Universität München
Großhaderner Straße 9
82152 Martinsried


The Hospital of the University of Munich, Germany, is one of the largest and most competitive university hospitals in Germany and Europe. 47 specialized hospitals, departments and institutions harboring excellent research and education provide patient care at the highest medical level wit h approximately 10.000 employees.

Open position for a postdoctoral scientist (F/M)

T cell immunology, autoimmunity

Topic:

Antigens of Pathogenic T cells from Patients with
Ankylosing Spondylitis (Morbus Bechterew)

Background:
In collaboration with rheumatologists, we are investigating the pathogeneses of ankylosing spondylitis (AS). AS is a chronic inflammatory disease which primarily affects the axial skeleton. It is presumably an autoimmune disease and has a very strong genetic bias to HLA-B*27:05. Because HLA molecules present antigenic peptides to cytotoxic T cells, this bias suggests that arthritogenic peptides may play a key role in the pathogenesis of AS by initiating the autoimmune attack of the T cells against spinal tissue. However, arthritogenic peptides have not yet been identified. The current project aims at identifying such peptides in order to reveal new insights into the pathogenesis of AS. All required techniques are established in our lab.

In pilot experiments we have identified several expanded T cell clones in AS patients. Their T cell receptors share structural motifs which supports our hypothesis. So far, one receptor is already cloned and ready to be examined by a novel, highly sensitive technique for analyzing T cell antigens (K. Siewert et al Nat.Med. 2012; A. Arakawa et al. J.Exp.Med. 2015).

We are now planning to investigate the T cell receptor repertoires in greater detail by further Illumina-next-generation sequencing with a particular focus on single cell analysis. We will then express further particularly interesting receptors, use them for antigen searches, and for investigating T cell receptors and peptide antigens in tissue samples from AS patients.


We seek:
Applicants should hold a doctoral degree (preferentially a PhD). Most importantly, he/she should be highly motivated, interested in joining an  interdisciplinary team, and ideally have some experience molecular biology.


We offer:
The position is funded by a DFG grant for 2 years. We offer a TV-L E13 position and are planning to start early 2019. Our well-equipped labs are at the new Biomedical Center. We encourage applications of women. In case of equal qualification, disabled individuals will be preferentially considered. Presentation costs cannot be reimbursed.


Please apply to:
Klaus.Dornmair@med.uni-muenchen.de
Institute for Clinical Neuroimmunology
Biomedical Center and University Hospital of the LMU Munich
Großhaderner Str. 9, 82152 Martinsried, room N.B. 03.013
Tel. 089-2180-71664
http://ini.klinikum.uni-muenchen.de/dornmair_lab.


The laboratory of PD Dr. Naoto Kawakami at the Institute of Clinical Neuroimmunology seeks to fill the following position:

PhD Candidate (m/f)


The group employs experimental autoimmune encephalomyelitis (EAE) as an animal model of multiple sclerosis. Specifically, by using two-photon microscopy, we visualize autoantigen specific T cell motility throughout the entire process of T cell infiltration into the CNS in living animals (Bartholomäus et al., Nature 2009, Mues et al., Nature Medicine 2013, Pesic et al., J. Clin. Invest. 2013, Kyratsous et al., PNAS 2017).


For a new project part, we would like to further study the interactions of encephalitogenic T cells with the Blood-brain barrier and with glial cells as well as the resulting consequences by using intravital imaging together with advanced methods of molecular biology.


Candidates should hold a Master’s degree in Biology, Immunology or a related subject. We are looking for applicants who are highly motivated, good team players, and yet capable of working independently. We prefer candidates with basic experience in fluorescence/confocal microscopy, experimental animal handling, flow cytometry, and cell culture.

The salary will be in accordance with the German model for the public sector (TV-L E13, 65%). The University of Munich is an equal opportunity employer. Handicapped candidates with equal qualifications will be given preference. For more details about the group, please see http://www.klinikum.uni-muenchen.de/Institut-fuer-Klinische-Neuroimmunologie/en/forschung/ag_kawakami/ .


Please send your complete CV, certificates of university degrees and other relevant transcripts together with letters of recommendation to
PD Dr. Naoto Kawakami, PhD
Institute of Clinical Neuroimmunology,
Biomedical center, LMU Munich Grosshaderner Str 9,
82152 Martinsried Germany
naoto.kawakami@med.uni-muenchen.de


Das Institut für klinische Neuroimmunologie sucht ab dem 01.12.2018 eine/n


Medizinische/n Fachangestellte/n bzw. Arzthelfer/in für mindestens 30 Stunden/Woche zur Mitarbeit in unserer Neuroimmunologischen Ambulanz
Eine erfolgreich abgeschlossene Ausbildung zur/zum Medizinische/n Fachangestellte/n bzw. Arzthelfer/in setzen wir voraus.

In enger Zusammenarbeit mit der Klinik für Neurologie und den niedergelassenen Neurologen behandeln wir Patienten mit neuroimmunologischen Erkrankungen. Für unsere MS-Ambulanz suchen wir eine Mitarbeiterin, die Freude am Umgang mit unseren Patienten hat (m/w)


Ihr Aufgabenbereich:
Terminvergabe, Aufnahme und Betreuung von Patienten, Telefondienst
Bearbeitung und Versand von Blutproben
Enge Kooperation mit den Ärzten sowie Unterstützung der Ärzte
Blutentnahmen für Laboruntersuchungen, intramuskuläre Injektionen unter Verantwortung des Arztes/der Ärztin, EKG
administrative Tätigkeiten

Unsere Anforderungen:
Fachliche, organisatorische und kommunikative Kompetenz
Freude an der Teamarbeit und im Umgang mit Menschen
Sehr gute Deutsch- und gute Englischkenntnisse
Grundlegende PC-Kenntnisse (Excel, Word)

Unser Angebot:
Wir bieten eine interessante und verantwortungsvolle Tätigkeit in einem kollegialen und engagierten Team. Der Vertrag ist auf ein Jahr befristet, eine anschließende Weiterbeschäftigung ist aber grundsätzlich vorgesehen. Die Eingruppierung (TVöD) erfolgt entsprechend Ihrer Berufserfahrung. Die Arbeitszeit beträgt mindestens 30 Stunden/Woche.



Schwerbehinderte Bewerber/innen werden bei ansonsten im Wesentlichen gleicher Eignung bevorzugt. Vorstellungskosten können leider nicht erstattet werden. Für weitere Informationen wenden Sie sich bitte an Margit Josel, Sekretariat, 089-4400-74781
Ihre Bewerbung richten Sie bitte an:

Klinikum der Universität München
Institut für Klinische Neuroimmunologie
zu Händen Frau M. Josel
Klinikum der Universität München
Marchioninistr. 15
81377 München-Großhadern
Margit.Josel@med.uni-muenchen.de


Bitte beachten Sie bei der Übersendung Ihrer Bewerbung per E-Mail, dass bei diesem Übermittlungsweg Ihre Daten unverschlüsselt sind und unter Umständen von Unbefugten zur Kenntnis genommen oder auch verfälscht werden können. Gerne können Sie uns Ihre Unterlagen per Post zukommen lassen.