Ausgewählte Publikationen

FGF22 signaling regulates synapse formation during post-injury remodeling of the spinal cord

EMBO J. 2015 Mar 12. pii: e201490578. [Epub ahead of print]

Following spinal cord injury, transected projections form detour circuits that circumvent the lesion and contribute to functional recovery. The formation of new synaptic contacts is a crucial step of the process, but its molecular regulation is currently not understood. Here, we show that: • FGF22 and FGF22 receptors are expressed in the adult nervous system. • FGF22 deficiency or deletion of FGF22 receptors restricts the formation and maturation of new synapses in the injured spinal cord. • Genetic disruption of FGF22 signaling impedes spontaneous functional recovery following spinal cord injury. [mehr...]
 

Abundant Expression of Guidance and Synaptogenic Molecules in the Injured Spinal Cord

PLoS ONE 9(2): e88449.

Here we investigate which molecules could regulate the formation of neuronal circuits in the injured spinal cord. Using an situ hybridization screen we show that many of the guidance and synaptogenic cues that regulate neuronal circuit formation in development are also present in the adult CNS and therefore likely contribute to the remodelling of axonal connections in the injured spinal cord. [mehr...]
 

STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury

EMBO Rep. 2013 Sep 30;14(10):931-7. doi: 10.1038/embor.2013.117

Here we show that viral gene transfer of the transcription factor STAT3 can induce remodeling if unlesioned fibers and thereby improve functional recovery after spinal cord injury. [mehr...]
 

Single Collateral Reconstructions Reveal Distinct Phases of Corticospinal Remodeling after Spinal Cord Injury

PLoS One. 2012;7(1):e30461. Epub 2012 Jan 24

Here, we describe distinct phases of axonal remodelling after spinal cord injury. [mehr...]
 

In vivo imaging reveals a phase-specific role of STAT3 during central and peripheral nervous system axon regeneration

Proc Natl Acad Sci U S A. 2011 Apr 12;108(15):6282-7

Here, we show that the transcription factor STAT3 regulates the initiation but not the elongation phase of axonal regeneration in the PNS and CNS. [mehr...]
 

A reversible form of axon damage in experimental autoimmune encephalomyelitis and multiple sclerosis

Nature Medicine 2011 Vol. 17 No. 4

Here, we use in vivo multiphoton imaging to identify a novel form of axonal degeneration that contributes to axon loss in multiple sclerosis and its animal model. [mehr...]
 

Neuronal repair and replacement in spinal cord injury

J Neurol Sci. 2008 Feb 15;265(1-2):63-72. Epub 2007 Jun 12

Here, I discuss how injured axonal connections can be repaired after spinal cord injury. [mehr...]
 

Cognitive outcome following brain injury and treatment with an inhibitor of Nogo-A in association with an attenuated downregulation of hippocampal growth-associated protein-43 expression

J Neurosurg. 2007 Oct;107(4):844-53

Here, we show how the consequences of traumatic brain injury can be therapeutically ameliorated. [mehr...]
 

Imaging axonal transport of mitochondria in vivo

Nat Methods. 2007 Jul;4(7):559-61. Epub 2007 Jun 10

Here, we establish a novel approach that allows to image the transport of fluorescently labelled mitochondria in the intact nervous system. [mehr...]
 

Transgenic labeling of the corticospinal tract for monitoring axonal responses to spinal cord injury

Nat Med. 2005 Dec;11(12):1355-60. Epub 2005 Nov 13

Here, we describe how mice with a fluorescently labelled corticospinal tract can improve the analysis of axonal plasticity after spinal cord injury. [mehr...]
 

Remodeling of Axonal Connections Contributes to Recovery in an Animal Model of Multiple Sclerosis

J Exp Med. 2004 Oct 18;200(8):1027-38

Here, we show that axonal connections are remodelled on multiple anatomical levels in response to a targeted inflammatory lesion of the spinal cord. [mehr...]
 

The injured spinal cord spontaneously forms a new intraspinal circuit in adult rats

Nat Neurosci. 2004 Mar;7(3):269-77. Epub 2004 Feb 15

Here, we demonstrate that the spontaneous formation of intraspinal detour circuits contributes to functional recovery after spinal cord injury. [mehr...]
 

Inflammation, degeneration and regeneration in the injured spinal cord: insights from DNA microarrays

Trends in Neurosciences, Volume 26, Issue 10, 555-563

Here, we discuss how microarray analyses can improve our understanding of spinal cord injuries. [mehr...]
 
 
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