DFG Graduiertenkolleg 1202 » Publications

Publications

A Originialarbeiten

 

 BildPublikationen

Originalarbeiten

n

Summe JIF

2005

1

7,2

2006

4

44,0

2007

5

31,7

2008

10

123,7

2009

19

132,4

2010

15

129,3

2011

18

109,5

2012

9

61,2

2013

15

115,3

2014

12

78,0

2015 

14

90,3

2016

2

9,6

Summe

123

937,54

 

Mitglieder des Graduiertenkollegs sind fett markiert, durch das Graduiertenkolleg finanzierte Stipendiaten zusätzlich unterstrichen, anderweitig finanzierte Stipendiaten fett grau markiert.

 

Members of the Research Training Group DFG-GRK 1202 are marked in bold, scholarship students funded by the Research Training Group are additionaly underlined. Otherwise funded students are marked in bold and grey.

 

2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

 

2005

 

1. Patole P, Zecher D, Pawar RD, Schlöndorff D, Anders HJ.

Lupus nephritis suppressed by G-rich DNA.

J Am Soc Nephrol 2005; 16:3273-3280 (JIF 7,2)

 

2006

 

2. Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G.

5’-triphosphate RNA is the ligand for RIG-I.

Science 2006; 314:994-997 (JIF 26,4)

 

3. Patole PS, Pawar RD, Ellwart A, Schmid H, Kretzler, Anders HJ.

Expression and regulation of Toll-like receptors in immune complex glomerulonephritis.

Nephrol Dial Transplant 2006; 21:3062-73 (JIF 3,2)

 

4. Pawar RD, Patole PS, Ellwart A, Segerer S, Schlöndorff D, Anders HJ.

Ligands to nucleic acid-specific Toll-like receptors and the onset of lupus nephritis.

J Am Soc Nephrol 2006; 17:3365-73 (JIF 7,2)

 

5. Pawar RD, Patole PS, Zecher D, Kretzler M, Schlöndorff D, Anders HJ.

Toll-like receptor-7 modulates immune complex glomerulonephritis.

J Am Soc Nephrol 2006; 17:141-9 (JIF 7,2)

 

2007

 

6. Bauer C, Bauernfeind F, Orban M, Schnurr M, Lehr HA, Endres S,      Eigler A, Dauer M.

Dendritic cell-based vaccination can be combined with gemcitabine to increase survival in a murine pancreatic carcinoma model.

Gut 2007; 56:1275-82(JIF 7,7)

 

7. Bourquin C, Schmidt L, Hornung V, Wurzenberger C, Anz D,      Sandholzer N, Schreiber S, Voelkl A, Hartmann G, Endres S.

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response.

Blood 2007; 109:2953-60 (JIF 10,4)

 

 

 

8. Lech M, Garlanda C, Mantovani A, Kirschning C, Schlöndorff D, Anders HJ.

Different roles of Tir8/Sigirr on Toll-like receptor signaling in intrarenal antigen-presenting cells and tubular epithelial cells.

Kidney Int 2007; 72:182-92(JIF 4,9)

 

9. Patole PS, Pawar RD, Lichtnekert J, Lech M, Kulkarni OP, Allam R, Segerer S, Anders HJ.

Coactivation of Toll-like receptor (TLR) 3 and TLR7 in immune-complex glomerulonephritis.

J Autoimmunity 2007; 29:52-9 (JIF 1,5)

 

10. Pawar RD, Allam R, Kulkarni O, Lech M, Segerer S, Anders HJ.

Inhibition of Toll-like receptor (TLR)-7 or TLR7 plus TLR9 prevents glomerulonephritis and lung injury in experimental lupus.

J Am Soc Nephrol 2007; 18:1721-31(JIF 7,2)

 

2008

 

11. Allam R, Pawar RD, Kulkarni OP, Hornung V, Hartmann G, Segerer S, Akira S, Endres S, Anders HJ.

Viral 5'-triphosphate RNA and non-CpG DNA aggravate autoimmunity and lupus nephritis via distinct TLR-independent immune responses.

Eur J Immunol 2008; 38:3487-98 (JIF 4,6)

 

12. Bourquin C, Anz D, Zwiorek K, von der Borch P, Wurzenberger C, Lanz A, Golic M, Fuchs S, Winter G, Coester C, Endres S.

Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity.

J Immunol 2008; 181:2990-8 (JIF 7,3)

 

13. Cui S, Eisenächer K, Kirchhofer A, Brzózka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.

Mol Cell 2008; 29:169-179 (JIF 14,0)

 

14. Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU.

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.

Proc Natl Acad Sci U S A 2008; Oct 28;105(43):16743-8 (JIF 9,6)

 

15.Hornung V, Bauernfeind F, Halle A, Samstad E, Kono H, Rock K, Fitzgerald K, Latz E.

Silica crystals and aluminum salts mediate NALP-3 inflammasome activation via phagosomal destabilization.

Nat Immunol 2008; 9:847-56 (JIF 27,6)

  

16. Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, König M, Kalinke U, Pasparakis M, Tschopp J.

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

Immunity 2008; 28:651-61 (JIF 18,0)

 

17. Pfaller CK, Conzelmann KK.

Measles virus V protein is a decoy substrate for the kinase IKK a and prevents Toll-like receptor 7/9-mediated interferon induction.

J Virol 2008; 82:12365-73 (JIF 5,3)

 

18. Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Shulga Morskaya S, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E, Kato H, Akira S,

Meyers R, Häcker G, Neuenhahn M, H. Busch D, Rothenfusser S, Prinz M, Hornung V, Endres S, Tüting T, Hartmann G.

5´-triphosphate-siRNA: turning gene silencing and RIG-I activation against melanoma.

Nat Med 2008; 14:1256-63 (JIF 26,4)

 

29. Savarese E, Steinberg C, Pawar RD, Reindl W, Akira S, Anders HJ, Krug A.

TLR7 is required for pristane-induced snRNP antibody production and lupus nephritis.

Arthritis Rheum 2008; 58:1107-15 (JIF 7,8)

 

 

20. Wei T, Gong J, Jamitzky F, Heckl WM, Stark RW, Rössle SC.

LRRML: a conformational database and an XML description of leucine-rich repeats (LRRs).

BMC Struct Biol 2008; 8:47-50 (JIF 3,1)

 

2009

 

 

21. Anz D*, Thaler R*, Stephan N, Waibler Z, Trauscheid JM, Scholz C, Kalinke U, Barchet W, Endres S, Bourquin C. *Autoren leisteten gleichwertigen Beitrag

Activation of melanoma differentiation-associated gene 5 (MDA-5) causes rapid involution of the thymus.

J Immunol 2009; 182:6824-33 (JIF 6,1)

 

 

22. Flammiger A, Besch R, Cook A, Maier T, Sturm R, Berking C.

SOX9 and SOX10 but not BRN2 are required for nestin expression in human melanoma cells.

J Invest Dermatol 2009; 129:945-53 (JIF 4,8)

 

 

23. Lichtnekert J, Vielhauer V, Zecher D, Kulkarni OP, Clauss S, Segerer S, Hornung V, Mayadas TN, Beutler B, Akira S, Anders HJ.

Trif is not required for immune complex glomerulonephritis: Dying cells activate mesangial cells via Tlr2/Myd88 rather than Tlr3/Trif.

Am J Physiol Renal Physiol 2009; 296:F867-74 (JIF 4,4)

 

 

24. Myong S, Cui S, Cornish PV, Kirchhofer A, Gack MU, Jung JU, Hopfner KP, Ha T.

Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.

Science 2009; 323:1070-4 (JIF 26,4)

 

 

25. Pawar RD, Castrezana-Lopez L, Allam R, Kulkarni OP, Segerer S, Radomska E, Meyer T, Meyer-Schwesinger C, Akis N, Gröne HJ, Anders HJ.

Bacterial lipopeptide triggers massive albuminuria in murine lupus nephritis by activating Toll-like receptor 2 at the glomerular filtration barrier.

Immunology 2009; 128(1 Suppl):e206-21. (JIF 3,4)

 

 

 26. Pippig DA, Hellmuth JC, Cui S, Kirchhofer A, Lammens K, Lammens A, Schmidt A, Rothenfusser S, Hopfner KP.

The regulatory domain of the RIG-I family ATPase LGP2 senses double-stranded RNA.

Nucleic Acids Res 2009; 37:2014-25(JIF 7,0)

 

 

27. Schnurr M, Orban M, Robson NC, Shin A, Braley H, Airey D, Cebon J, Maraskovsky E, Endres S.

Iscomatrix™ adjuvant induces efficient cross-presentationof tumor antigen by dendritic cells via rapid cytosolic antigendelivery and processing via tripeptidyl peptidase II.

J Immunol 2009; 182:1253-9. (JIF 6,1)

 

28. Wurzenberger C, Koelzer VH, Schreiber S, Anz D, Vollmar AM, Schnurr M, Endres S, Bourquin C.

Short-term activation induces multifunctional dendritic cells that generate potent antitumor T-cell responses in vivo.

Cancer Immunol Immunother2009; 58:901-13. (JIF 3,7)

 

29. Flür K, Allam A, Zecher D, Kulkarni OP, LichtnekertL, SchwarzM, Beutler B, Vielhauer V, Anders HJ.

Viral RNA induces type I interferon-dependent cytokine release and cell death in mesangial cells via melanoma-differentiation-associated gene-5. Implications for viral infection-associated glomerulonephritis.

Am J Pathol 2009; 175:2014-22. (JIF 5,7)

 

30. Lech L, Avila-Ferrufino A, Allam R,Segerer S, Khandoga A, Krombach F, Garlanda C, Mantovani A, Anders HJ.

Resident myeloid cells prevent postischemic acute renal failure by help of single immunoglobulin interleukin-1 receptor-related protein.

J Immunol 2009; 183:4109-18 (JIF 6,1)

 

31. Hägele H, Allam R, Pawar RD, Anders HJ.

Double-stranded RNA activates type I interferon secretion in glomerular endothelial cells via retinoic acid-inducible gene (RIG)-1.

Nephrol Dial Transplant 2009; 24:3312-8. (JIF 3,2)

 

32. Hägele H, Allam R, Pawar RD, Reichel C, Krombach F, Anders HJ.

Double-stranded DNA activates glomerular endothelial cells and enhances albumin permeability via a Toll-like receptor-independent cytosolic DNA recognition pathway.

Am J Pathol 2009; 175:1896-904. (JIF 5,7)

 

33. Ramming A, Thümmler K, Schulze-Koops H, Skapenko A.

Homotypic T-cell/T-cell interaction induces T-cell activation, proliferation, and differentiation.

Hum Immunol 2009; 70(11):873-81. (JIF 3,1)

 

 

2009: Neu in press oder publiziert seit 25. März 2009 (Drucklegung Fortsetzungsantrag)

 

34. Schmidt A*, Schwerd T*, Hamm W*, Hellmuth JC, Cui S, Wenzel M, Hoffmann F, Michallet MC, Besch R, Hopfner KP, Endres S, Rothenfusser S. *Autoren leisteten gleichwertigen Beitrag.

5’-triphosphate RNA requires base-paired structures to activate anti-viral signaling via RIG-I

Proc Natl Acad Sci USA 2009; 106:12067-72.(JIF 9,5)

 

35. Allam R, Lichtnekert J, Moll A, Taubitz A, Vielhauer V, Anders HJ.

Viral RNA and DNA sense common antiviral responses including type I interferons in mesangial cells.

J Am Soc Nephrol 2009; 20:1986-96. (JIF 7,1)

 

36. Wei T, Gong J, Jamitzky F, Heckl WM, Stark RW, Rössle SC.

Homology modeling of human Toll-like receptors TLR 7, 8 and 9 ligand-binding domains.

Protein Sci 2009; 18:1684-1691. (JIF 3,1)

 

37. Besch R*, Poeck H*, Hohenauer T, Senft D, Haecker G, Berking C, Hornung V, Endres S, Ruzicka T, Rothenfusser S*, Hartmann G*. *Autoren leisteten gleichwertigen Beitrag.

Proapoptotic signalling by RIG-I and MDA-5 results in tumorspecific apoptosis independent of type I interferons in melanoma.

J Clin Invest 2009; 119:2399-411. (JIF 16,9)

 

38. Berchtold C, Panthel K, Jellbauer S, Koehn B, Roider E, Partille M, Heesemann J, Endres S, Bourquin C, Rüssmann H.

Superior protective Immunity against murine listeriosis by combined vaccination with CpG DANN and recombinant Salmonella.

Infect Immun 2009; 77:5501-8. (JIF 4,0)

 

39. Bourquin C, Schmidt L, Lanz AL, Storch B, Wurzenberger C, Anz D, Sandholzer S, Mocikat R, Berger M, Poeck H, Hartmann G, Hornung V, Endres S.

Immunostimulatory RNA oligonucleotides induce an effective antitumoral NK-cell response through the Toll-like receptor 7.

J Immunol 2009; 183:6078-86. (JIF 6,1)

 

 

  

2010

 

40. Anz D, Koelzer VH, ModerS, Thaler R, Schwerd T, Lahl K, Sparwasser T, Besch R, Poeck H, Hornung V, Hartmann G, Rothenfusser S, Bourquin C, Endres S. (* corresponding author)

Immunostimulatory RNA blocks suppression by regulatory T cells.

J Immunol 2010; 184:939-46. (JIF 6,1)

 

41. Kirchhofer A, Helma J, Schmidthals K, Frauer C, Cui S, Karcher A, Pellis M, Muyldermans S, Casas Delucchi C, Cardoso CM, Leonhardt H, Hopfner KP, Rothbauer U.

Modulation of protein properties in living cells using nanobodies.

Nat Struct Mol Biol 2010; 17:133-8 (JIF 11,0)

 

42. Gong J, Wei T, Stark RW, Jamitzky F, Heckl WM, Anders HJ, Lech M, Rössle SC.

Inhibition of the Toll-like receptors TLR4 and 7 signaling pathways by SIGIRR: a computational approach.

J Struct Biol, 2010; 169:323-30. (JIF 4,1)

 

43. Wei T, Gong J, Jamitzky F, Heckl WM, Rössle CS, Stark RW.

Homology modeling of Toll-like receptor ectodomains using a leucine-rich repeat assembling method.

J Mol Model, 2010; 18(8):1684-91 (JIF 2,0)

 

44. Lech M, SkuginnaV, KulkarniOP, GongJ, WeiT, StarkRW, Garlanda C, Mantovani A, Anders HJ

Lack of SIGIRR/TIR8 aggravates hydrocarbon oil-induced systemic lupus.

J Pathol 2010; 220:596-607. (JIF 5,1)

 

45. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.

Nature 2010; 464:1357-61 (JIF 34,5)

 

46. Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M, Tschopp J, Endres S, Latz E, Schnurr M.

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.

Gut 2010; 59(9):1192-9 (JIF 9,8)

 

47. Bourquin C, von der Borch P, Zoglmeier Ch, Anz D, Sandholzer N, Wurzenberger C, Denzel A, Kammerer A, Zimmermann W, Endres S.

Efficient eradication of subcutaneous but not of autochthonous gastric tumors by adoptive T cell transfer in a SV40 T antigen mouse model.

J Immunol  2010; 185:2580-8. (JIF 6,1)

 

48. Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel Ch, Hartmann G, Hornung V, Ruland J.

RIG-I is a dual activator of Card9 and inflammasome signaling for IL-1β production upon RNA virus recognition.

Nat Immunol 2010; 11:63-9. (JIF 25,1)

 

49. Lech M, Avila-Ferrufino A, Skuginna V, Anders HJ.

Quantitative expression of RIG-like helicase, NOD-like receptor and inflammasome-related mRNAs in humans and mice.

Int Immunol; 22:717-28 (JIF 3,4)

 

50. Lassen S, Lech M, Römmele C, Mittruecker HW, Mak TW, Anders HJ.

Ischemia Reperfusion Induces IFN Regulatory Factor 4 in Renal Dendritic Cells, which Suppresses Postischemic Inflammation and Prevents Acute Renal Failure.

J Immunol 2010;185(3):1976-83 (JIF 6,1)

 

51. Thümmler K, Leipe J, Ramming A, Schulze-Koops H, Skapenko A.

Immune regulation by peripheral Tregs induced upon homotypic T cell/T cell interactions.

J Leukoc Biol 2010; 88(5):1041-50 (JIF 4,4)

 

52. Thümmler K*, Häntzschel N.*, Skapenko A, Schulze-Koops H, Pich A.

Surfactant-Free Poly(styrene-co-glycidyl methacrylate) Particles with Surface-Bound Antibodies for Activation and Proliferation of Human T Cells.

Bioconjug Chem 2010; 21:867-74. (JIF 4,35)*contributed equally

 

53. Bourquin C, Wurzenberger C, Fuchs S, Anz D, Weigel S, Sandholzer N, Winter G, Coester C, Endres S.

Delivery of immunostimulatory RNA oligonucleotides by gelatin nanoparticles triggers an efficient antitumoral response.

J Immunother 2010; 33:935-44; (JIF 4,8)

 

54. Bourquin C, von der Borch P, Zoglmeier C, Anz D, Sandholzer N, Suhartha N, Wurzenberger C, Denzel A, Kammerer R, Zimmermann W, Endres S.

Efficient eradication of subcutaneous but not of autochthonous gastric tumors by adoptive T cell transfer in an SV40 T antigen mouse model.

J Immunol 2010; 185:2580-8. (JIF 5.5) 

2011

 

55. Schueller V, Heidegger S, Sandholzer N, Suhartha N, Nickels P, Endres SBourquin C, Liedl T.

Cellular immunostimulation by CpG-sequence-coated DNA origami structures.

ACS Nano 2011; 5:9696-702. (JIF 12.1) 

 

56. Allam R, Darisipudi MN, Lichtnekert J, Rupanagudi KV, Tschopp J, Anders HJ.

Cutting edge: Cyclic polypetide and aminoglycoside antibiotics trigger interleukin-1ß secretion by activating the NLRP3 inflammasome.        

J Immunol 2011, 186:2714-8. (JIF 5,6)

 

57. Schuhmann KM, Pfaller CK, Conzelmann KK.

The measles virus V protein binds to p65 (RelA) to suppress NF-kappaB activity.

J Virol 2011; 85:3162-71. (JIF 5,3)

 

58. Rieder M, Brzózka K, Pfaller CK, Cox JH, Stitz L, Conzelmann KK.

Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity.

J Virol 2011; 85:842-52. (JIF 5,3)

 

59. Zoglmeier C, Bauer H, Noerenberg D, Wedekind G, Bittner P, Sandholzer N, Rapp M, Anz D, Endres S, Bourquin C.

CpG blocks immune suppression by myeloid-derived suppressor cells in tumor-bearing mice.

Clin Cancer Res 2011; 17:1765-75; (JIF 6,7)

 

60. Skuginna V, Lech M, Allam R, Clauss S, Susanti HE, Römmele C, Garlanda C, Mantovani A, Anders HJ.

Toll-like receptor signalling and SIGIRR in renal fibrosis upon unilateral ureteral obstruction.

PLoS One 2011; 6:e19204. (JIF 4,4)

 

61. Darisipudi MN, Allam R, Rupanagudi, Anders HJ.

Polyene macrolide antifungal drugs trigger interleukon-1ß secretion by activating the NLRP3 inflammasome.

PLoS One 2011; 6:e19588. (JIF 4,4)

 

62. Lech M, Römmele C, Kulkarni OP, Susanti HE, Migliorini A, Garlanda C, Mantovani A, Anders HJ.

Lack of the long pentraxin PTX3 promotes autoimmune lung injury but not glomerulonephritis in, murine systemic lupus erythematosus.

PLoS One 2011; 6:e20118. (JIF 4,4)

 

63. Lech M, Weidenbusch M, Kulkarni OP, Ryu M, Darisipudi MN, Susanti HE, Mittruecker HW, Mak TW, Anders HJ.

Interferon-regulatory factor-4 deficiency abrigates lupus-like nephritis despite enhancing systemic cytokine production.

J Am Soc Nephrol 2011; 22:1443-52. (JIF 8,3)

 

64. Duewell P, Kisser U, Heckelsmiller K, Hoves S, Stoitzner P, Morelli AB, Koernig S, Clausen BE, Dauer M, Eigler A, Anz D, Bourquin C, Maraskovsky E, Endres S, Schnurr M.

ISCOMATRIX adjuvant combines immune activation with antigen delivery to dendritic cells in vivo leading to effective cross-priming of CD8+ T cells.

J of Immunol 2011; 187:55-63. (JIF 5,6)

 

65. Lech M, Kantner C, Kulkarni O, Ryu M, Vlasova E, Heesemann J, Anz D, Endres S, Kobayashi K, Flavell RA, Martin J, Anders HJ.

Interleukin-1 receptor-associated kinase-M suppresses systemic lupus erythematosus.

Ann Rheum Dis 2011; 70:2207-17.  (JIF 9,1)

 

66. Darisipudi MN, Kulkarni OP, Sayyed SG, Ryu M, Migliorini A, Sagrinati C, Parente E, Vater A, Eulberg D, Klussmann S, Romagnani P, Anders HJ.

Dual blockade of the homeostatic chemokine CXCL12 and the proinflammatory chemokine CCL2 has additive protective effects on diabetic kidney disease.

Am J Pathol 2011; 179:116-24. (JIF 5,7)

 

67. Anz D, Mueller W, Golic M, Kunz WG, Rapp M, Koelzer VH, Ellermeier J, Ellwart JW,Schnurr M, Bourquin C, Endres S.

CD103 is a hallmark of tumor-infiltrating regulatory T cells.

Int J Cancer 2011; 129:2417-26. (JIF 4,7)

 

68. Jacobs C, Duewell P, Heckelsmiller K, Wei J, Bauernfeind F, Ellermeier J, Kisser U, Bauer CA, Dauer M, Eigler A, Maraskovsky E, Endres S, Schnurr M.

An ISCOM vaccine combined with a TLR9 agonist breaks immune evasion mediated by regulatory T cells in an orthotopic model of pancreatic carcinoma.

Int J Cancer 201; 128:897-907 (JIF 4,7)

 

69. Bourquin C, Hotz C, Noerenberg D, Völkl A, Heidegger S, Storch B, Sandholzer N, Wurzenberger C, Anz D, Endres S.

Systemic cancer therapy with a small molecule agonist of Toll-like receptor 7 can be improved by circumventing TLR tolerance.

Cancer Res 2011; 71:5123-33. (JIF 7,5)

 

70. Lichtnekert J, Kulkarni OP, Mulay SR, Rupanagudi KV, Ryu M, Allam R, Vielhauer V, Muruve D, Lindenmeyer MT, Cohen CD, Anders HJ.

Anti-GBM glomerulonephritis Involves IL-1 but is independent of NLRP3/ASC inflammasome-mediated activation of caspase-1.

PLOS 2011; 6:e26778. (JIF 4,4)

 

71. Dombrowski Y, Peric M, Koglin S, Kammerbauer C, Göss C, Anz D, Simanski M, Gläser R, Harder J, Hornung V, Gallo RL, Ruzicka T, Besch R, Schauber J.

Cytosolic DNA triggers inflammasome activation in keratinocytes in psoriatic lesions.

Sci Transl Med 2011;3:82ra38. (JIF 3,5)

 

72. Weidenbusch M, Kulkarni OP, Ryu M, Darisipudi MN, Susanti HE, Mittruecker HW, Mak TW, Anders HJ.

IRF4 deficiency abrogates lupus nephritis despite enhancing systemic cytokine production.

J Am Soc Nephrol 2011 22:1443-52 (JIF 7,8)

 

2012

 

73. Dann A, Poeck H, Croxford A, Gaupp S, Kierdorf K, Knust M, Pfeifer D, Maihoefer C, Endres S, Kalinke U, Meuth S, Wiendl H, Knobeloch KP, Akira S, Waisman A, Hartmann G, Prinz M.

Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS.

Nat Neurosci 2011; 15:98-106 (JIF 14,2)

 

74. Wenzel M, Wunderlich M, Besch R, Poeck H, Willms S, Schwantes A, Kremer M, Sutter G, Endres S, Schmidt A, Rothenfusser S.

Cytosolic DNA triggers mitochondrial apoptosis via DNA-damage signalling proteins independently of AIM2 and RNA polymerase III.

J Immunol 2012; 188:394-403. (JIF 5,6)

 

75. Sparrer KM, Pfaller CK, Conzelmann KK.

 Measles virus C protein interferes with Beta interferon transcription in the nucleus

J Virol 2012; 86:796-805 (JIF 5,3)

 

76. Willibald J, Harder J, Sparrer KMJ, Conzelmann KK, Carell T.

Click-modified anandamide siRNA enables delivery and gene silencing in neuronal and immune cells.

J Am Chem Soc 2012; 134:12330-3. (JIF 11,4)

 

77. Senft D, Berking C, Graf SA, Kammerbauer C, Ruzicka T, Besch R.

Selective induction of cell death in melanoma cell lines through targeting of Mcl-1 and A1

PLoS One 2012; 7:e30821 (JIF 4,4)

 

78. Ryu M, Migliorini A, Miosge N, Gross O, Shankland S, Brinkkoetter PT, Hagmann H, Romagnani P, Liapis H, Anders HJ.

Plasma leackage through glomerular basement membrane ruptures triggers the proliferation of parietal epithelial cells and crescent formation in non-inflammatory glomerular injury

J Pathol 2012,DOI: 10.1002/path.4046. (JIF 7,3)

 

79. Allam R, Scherbaum CR, Darispudi MN, Mulay SP, Hägele H, Lichtenekert J, Hagemann JH, Rupanagudi KV, Ryu R, Schwarzenberger C, Hohenstein B, Hugo C, Uhl B, Reichel CA, Krombach F, Monestier M, Moreth M, Schaefer L,

Anders HJ.

Histones released from dying renal cells aggravates accute kidney injury via Toll-like receptor-2 and -4.

J Am Soc Nephrol 2012, 23(8):1575-88 (JIF 8,3)

 

80. Lech M, Susanti HE, Römmele C, Gröbmayr R, Günthner R, Anders HJ.

Quantitative expression of C-type lectin receptors in humans and mice.

Int J Mol Sc 2012, 13(8):10113-31 (JIF 2,2)

 

81. Bauer C, Duewell P, Lehr HA, Endres S, Schnurr M.

Protective and aggravating effects of Nlrp3 inflammasome activation in IBD models influence of genetic and environmentalfactors.

Dig Dis 2012; 30; 82-90 (JIF 2,4)

 

2013

 

82. Mulay SR, Kulkarni OP, Rupanagudi K, Migliorini A, Darispudi MN, Vilaysane A, Muruve D, Shu Y, Munro F, Liapis H, Anders HJ.

Calcium Oxalate crystals induce renal inflammation by NLRP3-mediated IL-1ß secretion.

J Clin Invest 2013; 123: 236-46 (JIF 13,1)

 

83. Motz C, Schuhmann KM, Kirchhofer A, Moldt M, Witte G, Conzelmann KK, Hopfner KP.

Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling.

Science 2013; 339: 690-3 (JIF 31,2)

 

84. Ellermeier J, Wei J, Duewell P, Hoves S, Sieg MR, Adunka T, Noerenberg D, Anders HJ, Mayr D, Poeck H, Hartmann G, Endres S, Schnurr M.

Therapeutic efficacy of bifunctional siRNA combining TGF-ß1 silencing with RIG-I

Cancer Res 2013; 73: 1709-20 (JIF 7,9)

 

85. Lech M, Römmele C, Gröbmayr R, Eka Susanti H, Kulkarni OP, Wang S, Gröne HJ, Uhl B, Reichel C, Krombach F, Garlanda C, Mantovani A, Anders HJ.

Endogenous and exogenous pentraxin-3 limits postischemic acute and chronic kidney injury.

Kidney Int 2013; 83: 647-61 (JIF 6,6)

 

86. Migliorini A, Ebid R, Scherbaum CR, Anders HJ.

The danger control concept in kidney disease: mesangial cells.

J Nephrol 2013; 26: 437-49 (JIF 1,7)

 

87. Hohenauer T, Berking C, Schmidt A, Haferkamp S, Senft D, Kammerbauer C, Fraschka S, Graf SA, Irmler M, Beckers J, Flaig M, Aigner A, Höbel S, Hoffmann F, Hermeking H, Rothenfusser S, Endres S,

Ruzicka T, Besch R.

The neural crest transcription factor Brn3a is expressed in melanoma an required for cell cycle progression and survival.

EMBO Mol Med 2013 5(6):919-34 (JIF 10,3)

 

88. Ramaiah SK, Günthner R, Lech M, Anders HJ.

Toll-Like Receptor and Accessory Molecule mRNA Expression in Humans and Mice as Well as in Murine Autoimmunity, Transient Inflammation, and Progressive Fibrosis.

Int J Mol Sci 2013; 14:13213-30. (JIF 2,5)

 

89. Kobold S, Völk S, Clauditz T, Küpper NJ, Minner S, Tufmann A, Düwell P, Lindner M, Koch I, Heidegger S, Merk M, Rothenfußer S, Schnurr M, Huber RM, Sauter G, Wilczak W, Endres S.

Interleukin-22 is frequently expressed in small- and large-cell lung cancer and promotes growth in chemotherapy-resistant cancer cells.

J Thorac Oncol 2013; 8:1032-1042. (JIF 3,7)

 

90. Heidegger S*, Anz D*, Stephan N, Bohn B, Herbst T, Fendler WP, Suhartha N, Sandholzer N, Kobold S, Hotz C, Eisenaecher K, Radtke-Schuller S, Endres S, Bourquin C.

Virus-associated activation of innate immunity induces rapid disruption of Peyer’s patches in mice.

Blood 2013; 122:2591-9. (JIF 9,1) * equal contribution

 

91. Migliorini A, Angelotti ML, Mulay SR, Kulkarni OO, Demleitner J, Dietrich A, Sagrinati C, Ballerini L, Peired A, Shankland SJ, H Liapsis, Romagnani P, Anders HJ.

The Antiviral Cytokines IFN-a and IFN-b Modulate Parietal Epithelial Cells and Promote Podocyte Loss Implications for IFN Toxicity, Viral Glomerulonephritis, and Glomerular Regeneration.

Am J Pathol 2013; 183:431-40 (JIF 4,5)

 

92. Rupanagudi KV, Kulkarni OP, Lichtnekert J, Darisipudi MN, Mulay SR, Schott B, Gruner S, Haap W, Hartmann G, Anders HJ.

Cathepsin S inhibition suppresses systemic lupus erythematosus and lupus nephritis because cathepsin S is essential for MHC class II-mediated CD4 T cell and B cell priming.

Ann Rheum Dis 2013: doi: 10.1136/annrheumdis-2013-203717. (JIF 9,1)

 

93. Zhou Q, Haupt S, Prots I, Thümmler K, Kremmer E, Lipsky PE, Schulze-Koops H, Skapenko A.

Mir-142-3p regulates cell proliferation by targeting Glycoprotein A repetitions predominant.

J Immunol 2013; 190:6579-88. (JIF 5,5)

 

94. Heidegger S, Kirchner SK, Stephan N, Bohn B, Suhartha N, Hotz C, Anz D, Sandholzer N, Stecher B, Rüssmann H, Endres S, Bourquin C.

TLR activation excludes circulating naive CD8+ T cells from gut-associated lymphoid organs in mice.

J Immunol 2013; 190:5313-20. (JIF 5.5)

 

95. Günthner R, Kumar VR, Lorenz G, Anders HJ, Lech M.

Pattern-recognition receptor signaling regulator mRNA expression in humans and mice, and in transient inflammation or progressive fibrosis.

Int J Mol Sc 2013, 14:18124-18147. (JIF 2,3)

 

96. Schmitt S, Saathoff F, Meissner L, Schropp EM, Lichtmannegger J, Schulz S, Eberhagen C, Borchard S, Aichler M, Adamski J, Plesnila N, Rothenfusser S, Kroemer G, Zischka H.

A semi-automated method for isolating functionally intact mitochondria from cultured cells and tissue biopsies.

Anal Biochem. 2013; 443: 66-74 (JIF 2,3)

 

2014

 

97. Kulkarni OP*, Hartter I*, Mulay SR*, Hagemann J, Darisipudi MN, Kumar Vr S, Romoli S, Thomasova D, Ryu M, Kobold S, Anders HJ.

Toll-Like Receptor 4-Induced IL-22 Accelerates Kidney Regeneration.

J Am Soc Nephrol 2014; 25:978-89. (JIF 8,9) * equal contribution

 

98. Bauer C, Sterzik A, Bauernfeind F, Duewell P, Conrad C, Kiefl R, Endres S, Eigler A, Schnurr M, Dauer M.

Concomitant gemcitabine therapy negatively affects DC vaccine-induced CD8+ T-cell and B-cell responses but improves clinical efficacy in a murine pancreatic carcinoma model.

Cancer Immunol Immunother 2014; 63:321-33 (JIF 3,6)

 

99. Wilson NS*, Duewell P*, Yang B, Li Y, Marsters S, Koernig S, Latz E, Maraskovsky E, Morelli A, Schnurr M*, Ashkenazi A*.

Inflammasome-dependent and -independent IL-18 production mediates immunity to the ISCOMATRIX adjuvant.

J Immunol 2014; 192:3259-68. (JIF 5,5) * equal contribution

 

100. Runge S*, Sparrer KM*, Lässig C*, Hembach K, Baum A, García-Sastre A, Söding J, Conzelmann KK, Hopfner KP*.

In vivo ligands of MDA5 and RIG-I in measles virus-infected cells.

PLoS Pathog 2014; 10:e1004081. (JIF 8,1) * equal contribution

 

101. Zhou Q*, Haupt S*, Kreuzer JT, Hammitzsch A, Proft F, Neumann C, Leipe J, Witt M, Schulze-Koops H, Skapenko A

Decreased expression of miR-146a and miR-155 contributes to an abnormal Treg phenotype in patients with rheumatoid arthritis.

Ann Rheum Dis 2014; in press (JIF 9,1) * equal contribution

 

102. Graf SA, Busch C, Bosserhoff AK, Besch R, Berking C.

SOX10 Promotes Melanoma Cell Invasion by Regulating Melanoma Inhibitory Activity.

J Invest Dermatol 2014; 134:2212-20. (JIF 6,4)

 

103. Duewell P, Steger A, Lohr H, Bourhis H, Hoelz H, Kirchleitner SV, Stieg MR, Grassmann S, Kobold S, Siveke JT, Endres S, and Schnurr M.

RIG-I-like helicases induce immunogenic cell death of pancreatic cancer cells and sensitize tumors toward killing by CD8+ T cells.

Cell Death Diff 2014, in press. (JIF 8,4) 

 

104. Roskopf CC, Schiller CB, Braciak TA, Kobold S, Schubert IA, Fey GH, Hopfner KP, Oduncu FS.

T cell-recruiting triplebody 19-3-19 mediates serial lysis of malignant B-lymphoid cells by a single T cell.

Oncotarget 2014; 5:6466-83. (JIF 6,6)

 

105. Lech M, Lorenz G, Kulkarni OP, Grosser MO, Stigrot N, Darisipudi MN, Günthner R, Wintergerst MW, Anz D, Susanti HE, Anders HJ.

NLRP3 and ASC suppress lupus-like autoimmunity by driving the immunosuppressive effects of TGF-β receptor signalling.

Ann Rheum Dis 2014. (JIF 9,3)

 

106. Anz D, Kruger S, Haubner S, Rapp M, Bourquin C, Endres S.

The dipeptidylpeptidase-IV inhibitors sitagliptin, vildagliptin and saxagliptin do not impair innate and adaptive immune responses.

Diabetes Obes Metab 2014; 16:569-72. (JIF 5,5)

 

107. Kobold S, Merk M, Hofer L, Peters P, Bucala R, Endres S.

The macrophage migration inhibitory factor (MIF)-homologue D-dopachrome tautomerase is a therapeutic target in a murine melanoma model.

Oncotarget 2014; 5:103-7. (JIF 6,6)

 

108. Sparrer KM, Krebs S, Jäger G, Santibanez S, Mankertz A, Blum H, Conzelmann KK.

Complete Genome Sequence of a Wild-Type Measles Virus Isolated during the Spring 2013 Epidemic in Germany.

Genome Announc 2014; 2(2): e00157-14.

 

2015

 

109. Hoffmann F, Schmidt A, Dittmann Chevillotte M, Wisskirchen C, Hellmuth JC, Willms S, Gilmore RH, Glas J, Folwaczny M, Müller T, Berg T, Spengler U, Fitzmaurice K, Kelleher D, Reisch N, Rice CM, Endres S,

Rothenfusser S.

Polymorphisms in MDA-5 link protein function to clearance of hepatitis C virus

Hepatology 2015; 61:460-70. (JIF 11,2)

 

110. Kobold S, Steffen J, Chaloupka M, Grassmann S, Henkel J, Castoldi R, Zeng Y, Chmielewski M, Schmollinger J, Schnurr M, Rothenfußer S, Schendel DJ, Abken H, Sustmann C, Niederfellner CG, Klein C,

Bourquin C, Endres S.

Selective bispezific T cell recruiting antibody enhances anti-tumor activity of adoptive T cell transfer.

J Natl Cancer Inst 2015; 107:364 (JIF 15.2)

 

111. Bauer C, Hees C, Sterzik A, Bauernfeind F, Mak ́Anyengo R, Duewell P, Lehr HA, Noessner E, Wank R, Trauzold A, Endres S, Dauer M, Schnurr M.

Pro- and anti-apoptotic proteins of the Bcl-2 family regulate sensitivity of pancreatic cancer cells towards gemcitabine and T cell-mediated cytotoxicity.

J Immunother 2015, 38:116-26. (JIF 3.4)

 

112. Weidenbusch M, Rodler S, Anders HJ.

Interleukin-22 in kidney injury and regeneration.

Am J Phys Renal Physiol 2015. (JIF 3,8)

 

113. Bauer C, Hees C, Sterzik A, Bauernfeind F, Mak´Anyengo R, Duewell P, Lehr HA, Noessner E, Wank R, Trauzold A, Endres S, Dauer M, Schnurr M.

Pro- and anti-apoptotic proteins of the Bcl-2 family regulate sensitivity of pancreatic cancer cells towards gemcitabine and T cell-mediated cytotoxicity.

Journal of Immunotherapy 2015; 38:116-26. (JIF 3,4)

 

114. Duewell P, Beller E, Kirchleitner S, Adunka T, Bourhis H, Siveke J, Mayr D, Kobold S, Endres S, Schnurr M.

Targeted activation of melanoma differentiation-associated protein 5 (MDA5) for immunotherapy of pancreatic carcinoma.

OncoImmunology 2015; Vol. 4, Iss. 10, 2015. (JIF 6,3)

 

115. Freier C, Kuhn C, Rapp M, Endres S, Mayr D, Friese K, Anz D, Jeschke U.

Expression of CCL22 and infiltration by regulatory T-cells are increased in the decidua of human miscarriage placentas.

American Journal of Reproductive Immunology 2015; 74:216-27. (JIF 2,7)

 

116. Kobold* S, Grassmann* S, Chaloupka M, Lampert C, Wenk S, Kraus F, Rapp M, Duewell P, Zeng Y, Schmollinger J, Schnurr M, Endres S#, Rothenfußer S#.

Impact of a new fusion receptor on PD-1-mediated immunosuppression in adoptive T cell therapy.

The Journal of the National Cancer Institute 2015; 107.

* contributed equally to this study, # share senior authorship (JIF 15,2)      

 

117. Heidegger S, Alexander J, Endres S, Bourquin C, Hotz C.

Mycoplasma hyorhinis-contaminated cell lines activate primary innate immune cells via a protease-sensitive factor.

PLOS ONE 2015;10:e0142523. (JIF 3,7)

 

118. Häcker G, Senft D, Weber A, Saathoff F, Berking C, Heppt M, Kammerbauer C, Rothenfusser S, Kellner S, Kurgys Z, Besch R.

In non-transformed cells Bak activates upon loss of anti-apoptotic Bcl-XL and Mcl-1 but in the absence of active BH3-only proteins.

Cell Death and Disease 2015; 26;6:e1996. (JIF 5,0)

119. Anz D, Rapp M, Eiber S, Koelzer VH, Thaler R, Haubner S, Knott M, Nagel S, Golic M, Wiedemann GM, Bauernfeind F, Wurzenberger C, Hornung V, Scholz C, Mayr D, Rothenfusser S, Endres S, Bourquin C.

Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression.

Cancer Res 2015; 75(21):4483-93. (JIF 9,3)

 

120. Heidegger S, Jarosch A, Schmickl M, Endres S, Bourquin C, Hotz C.

Mycoplasma hyorhinis-Contaminated Cell Lines Activate Primary Innate Immune Cells via a Protease-Sensitive Factor.

PLoS One 2015; 10:e0142523. (JIF 3,7)

 

121. Heidegger S, Gößl D, Schmidt A, Niedermayer S, Argyo C, Endres S, Bein T, Bourquin C.

Immune response to functionalized mesoporous silica nanoparticles for targeted drug delivery.

Nanoscale 2015; 8(2):938-48. (JIF 7,4)

 

122. Haupt S, Söntgerath VS, Leipe J, Schulze-Koops H, Skapenko A.

Methylation of an intragenic alternative promoter regulates transcription of GARP.

Biochimica et Biophysica Acta 2016; 1859(2):223-34. Epub 2015. (JIF 5,34)

   

2016

 

123. Hornig E, Heppt MV, Graf SA, Ruzicka T, Berking C.

Inhibition of histone deacetylases in melanoma - a perspective from bench to beside.

Experimental Dermatology 2016; 25(11):831-838. (JIF 2,7)

 

124. Matheis F, Heppt MV, Graf SA, Düwell P, Kammerbauer C, Aigner A, Besch R, Berking C.

A bifunctional approach of immunostimulation and uPAR inhibition shows potent antitumor activity in melanoma.

Journal of Investigative Dermatology 2016; 136(12):2475-2484. (JIF 6,9)

 



B Originalarbeiten von früheren Stipendiaten nach Abschluss der Förderung durch das Graduiertenkolleg

 

2009

 

1. Berger M, Ablasser A, Kim S, Bekeredjian-Ding I, Giese T, Endres S, Hornung V, Hartmann G.

TLR8-driven IL-12 dependent reciprocal and synergistic activation of NK cells and monocytes by immunstimulatory RNA.

J Immunother 2009; 32:262-71 (JIF 4,8)

 

2. Hornung V, Ablasser A, Charrel-Dennis M, Bauernfeind F, Horvath G, Caffrey DR, Latz E, Fitzgerald KA.

AIM2 recognizes cytosolic dsDNA and forms a caspase-1-activating inflammasome with ASC.

Nature 2009; 58:514-8 (JIF 28,8)

 

3. Gross O*, Poeck H*, Bscheider M, Dostert C, Hannesschläger N, Endres S, Hartmann G, Tardivel A, Schweighoffer E, Tybulewicz V, Mocsai A, Tschopp J, Ruland J. *Autoren leisteten gleichwertigen Beitrag.

Syk kinase signalling couples to the Nlrp3 inflammasome for anti-fungal host defence.

Nature 2009; 459:433-6 (JIF 28,8)

 

4. Sayyed SG*, Hägele H*, Kulkarni OP, Endlich K, Segerer S, Eulberg D, Klussmann S, Anders HJ. * shared first author

Podocytes express the homeostatic chemokine stromal cell-derived factor-1/CXCL12 which contributes to glomerulosclerosis, podocyte loss, and albuminuria in type 2 diabetes.

Diabetologia 2009 ; 52:2445-54 (JIF 6,4)

 

2011

 

5. Sayyed SG, Ryu M, Kulkarni OP, Schmid H, Lichtnekert J, Grüner S, Green L, Mattei P, Hartmann G, Anders HJ.

An orally active chemokine receptor CCR2 antagonist prevents glomerulosclerosis and renal failure in type 2 diabetes.

Kidney Int 2011; 80:68-78. (JIF 6,2)

 

6. Allam R, Sayyed SG, Kulkarni O, Lichtnekert J, Anders HJ.

Mdm2 promotes systemic lupus erythematosus and lupus nephritis.

J Am Soc Nephrol 2011; 22:2016-27 (JIF 8,3)

 

7. Lichtnekert J, Rupanagudi KV, Kulkarni O, Darisipudi MN, Allam R, Anders HJ.

Activated Protein C attenuates systemic Lupus erythematosus and Lupus nephritis in MRL-Fas(lpr) Mice.

J Immunol 2011; 187:3413-21. (JIF 5,7)

 

2012

 

8. Ribeiro A, Wörnle M, Motamedi N, Anders HJ, Gröne EF, Nitschko H, Kurktschiev P, Debiec H, Kretzler M, Cohen CD, Gröne HJ, Schlöndorff D, Schmid H.

Activation of innate immune defense mechanisms contributes to polyomavirus BK-associated nephropathy.

Kidney Int 2012; 81:100-11. (JIF 6,6)

 

2013

 

9. Hagemann JH, Haegele H, Müller S, Anders HJ.

Danger control programs cause tissue injury and remodeling.

Int J Mol Sci 2013 28;14:11319-46. (JIF 2,3)

 

10. Weidenbusch M*, Römmele C*, Schröttle A, Anders HJ.

Beyond the LUNAR trial. Efficacy of rituximab in refractory lupus nephritis.

Nephrol Dial Transplant 2013; 28:106-11. (JIF 3,6) * equal contribution

 

11. Hagemann JH, Thomasova D, Mulay SR, Anders HJ.

Nrf2 signalling promotes ex vivo tubular epithelial cell survival and regeneration via murine double minute (MDM)-2.

Nephrol Dial Transplant 2013; 28:2028-37 (JIF 3,6)

 

12. Mulay SR, Thomasova D, Ryu M, Kulkarni OP, Migliorini A, Bruns H, Gröbmayr R, Lazzeri E, Lasagni L, Liapis H, Romagnani P, Anders HJ.

Podocyte loss involves MDM2-driven mitotic catastrophe.

J Pathol 2013; 230:322-35 (JIF 7,6)

 

13. Schnurr M, Duewell P.

Breaking tumor-induced immunosuppression with 5'-triphosphate siRNA silencing TGFβ and activating RIG-I.

Oncoimmunology 2013; 2:e24170 (JIF: 6,3)

 

  

C Originalarbeiten nicht in A, weil zwar Graduiertenkolleg 1202 im Acknowledgement, aber kein Stipendiat als Ko-Autor

 

2006

 

1. Kerkmann M, Lochmann D, Weyermann J, Poeck H, Wagner M, Battiany J, Marschner A, Zimmer A, Endres S, Hartmann G.

Immunostimulatory properties of CpG-oligonucleotides are enhanced by the use of protamine nanoparticles.

Oligonucleotides 2006; 16:313-22 (JIF 3,1)

 

2007

 

2. Besch R, Berking C, Kammerbauer C, Degitz K.

Inhibition of urokinase-type plasminogen activator receptor induces apoptosis in melanoma cells by activation of p53.

Cell Death Differ 2007; 14:181-29 (JIF 8,3)

 

2008

 

3. Zwiorek K, Bourquin C, Battiany J, Winter G, Endres S, Hartmann G, Coester C.

Delivery by cationic gelatin nanoparticles strongly increases the immuno-stimulatory effects of CpG oligonucleotides.

Pharm Res 2008; 25:551-62 (JIF 2,8)

 

4. Shin A, Toy T, Rothenfusser S, Robson N, Vorac J, Dauer M, Stuplich M, Endres S, Cebon J, Maraskovsky E, Schnurr M.

P2Y receptor signaling regulates phenotype and IFN- a secretion of human plasmacytoid dendritic cells.

Blood 2008; 111:3062-9(JIF 10,1)

 

5. Haasters F, Prall WC, Anz D, Bourquin C, Pautke C, Endres S, Mutschler W, Docheva D, Schieker M.

Morphological and immunocytochemical characteristics indicate the yield of early progenitors and represent a quality control for human mesenchymal stem cell culturing.

J Anat 2009; 214:759-67 (JIF 2,5)

 

2009

 

6. Bakos R, Maier T, Besch R, Mestel D, Ruzicka T, Sturm R, Berking C.

Nestin and SOX9 and SOX10 transcription factors are co-expressed in melanoma.

Exp Dermatol; Epub ahead of print; (JIF 3,3)

 

7. Weber A, Kirejczyk Z, Besch R, Potthoff S, Leverkus M, Häcker G.

Pro-apoptotic signalling through Toll-like receptor 3 involves TRIF-dependent activation of caspase-8 and is under the control of inhibitor of apoptosis proteins in melanoma cells.

Cell Death Diff 2009; Epub ahead of print (JIF 7,5)

 

2010

 

8. Kulkarni OP, Sayyed S, Kantner C, Ryu M, Schnurr M, Sardy M, Leban J, Jankowski R, Ammendola A, Doblhofer R, Anders HJ.

4SC-101, a novel small molecule dihydroorotate dehydrogenase inhibitor, suppresses systemic lupus erythematosus in MRL-(Fas)lpr mice.

Am J Pathol 2010;176:2840-7. (JIF 5,7)

 

9. Ryu M, Kulkarni OP, Radomska E, Miosge N, Gross O, Anders HJ.

Bacterial CpG-DNA accelerates Alport glomerulosclerosis by inducing a M1 macrophage phenotype and TNF-α-mediated podocyte loss.

Kidney Int 2010; 79:189-98. (JIF 5,7)

 

2011

 

10. Bertossi A, Aichinger M, Sansonetti P, Lech M, Neff F, Pal M, Wunderlich FT, Anders HJ, Klein L, Schmidt-Supprian M.

Loss of Rouquin induces early death and immune deregulation, but not autoimmunity.

J Exp Med 2011; 208:1749-56. (JIF 14,7)

 

11. Maier T, Laubender RP, Sturm RA, Klingenstein A, Korting HC, Ruzicka T, Berking C.

Osteopontin expression in plasma of melanoma patients and in melanocytic tumours.

J Eur Acad Dermatol 2011; doi: 10.1111/j.1468-3083.2011.04210.x Epub ahead of print (JIF 3,4)

 

12. Anders HJ, Kurts C.

Innate immunity and dendritic cells in kidney disease and the Nobel Prize.

J Am Soc Nephrol 2011; 22:2139–2141 (JIF 8,3)

 

13. Anders HJ, Ryu M.

Renal microenvironments and macrophage phenotypes determine progression or resolution of renal inflammation and fibrosis.

Kidney Int. 2011; 80:915-25 (JIF 6,1)

 

14. Anz D, Eiber S, Scholz C, Endres S, Kirchner T, Bourquin C, Mayr D.

In breast cancer a high ratio of tumor-infiltrating intraepithelial CD8+ to FoxP3+ cells is characteristic for the medullary subtype.

Histopathology 2011; 59:965-74. (JIF 3.8)

 

2012

 

15. Ramming A, Druzd D, Leipe J, Schulze-Koops H, Skapenko A.

Maturation-related histone modifications in the PU.1 promoter regulate Th9 cell development.

Blood 2012; [Epub ahead of print] (JIF 10,1)

 

16. Sánchez E, García-Bermúdez M, Jiménez-Alonso J, de Ramón E, Sánchez-Román J, Ortego-Centeno N, Witte T, D'Alfonso S, Pons-Estel B, Anders HJ, Alarcón-Riquelme ME, Martín J.

Association study of IRAK-M and SIGIRR genes with SLE in a large European-descent population.

Lupus 2012; 21:1166-71. (JIF 2,6)

 

17. Seleznik GM, Reding T, Romrig F, Saito Y, Mildner A, Segerer S, Sun LK, Regenass S, Lech M, Anders HJ, McHugh D, Kumagi T, Hiasa Y, Lackner C, Haybaeck J, Angst E, Perren A, Balmer ML, Slack E, MacPherson A,

Manz MG, Weber A, Browning JL, Arkan MC, Rülicke T, Aguzzi A, Prinz M, Graf R, Heikenwalder M.

Lymphotoxin β receptor signaling promotes development of autoimmune pancreatitis.

Gastroenterology 2012; 143:1361-74. (JIF 11,7)

 

2013

 

18. Lech M, Anders HJ.

Macrophages and fibrosis: How resident and infiltrating mononuclear phagocytes orchestrate all phases of tissue injury and repair.

Biochim Biophys Acta 2013; 1832:989-97. (JIF 4,9)

 

19. Lech M, Anders HJ.

The Pathogenesis of Lupus Nephritis

J Am Soc Nephrol 2013; 24:1357-66. (JIF 9,0)

 

20. Besch R, Berking C.

POU transcription factors in melanocytes and melanoma.

Eur J Cell Biol 2013; 93:55-60. (JIF 3.2)

 

2014

 

21. Jeltsch KM, Hu D, Brenner S, Zöller J, Heinz GA, Nagel D, Vogel KU, Rehage N, Warth SC, Edelmann SL, Gloury R, Martin N, Lohs C, Lech M, Stehklein JE, Geerlof A, Kremmer E, Weber A, Anders HJ, Schmitz I,

Schmidt-Supprian M, Fu M, Holtmann H, Krappmann D, Ruland J, Kallies A, Heikenwalder M, Heissmeyer V.

Cleavage of roquin and regnase-1 by the paracaspase MALT1 releases their cooperatively repressed targets to promote TH17 differentiation.

Nat Immunol 2014 Nov;15:1079-89 (JIF 25,0)

 

D Übersichtsarbeiten

 

 

2005

 

1. Anders HJ, Zecher D, Pawar RD, Patole PS.

Molecular mechanisms of autoimmunity triggered by microbial infection.

Arthritis Res Ther 2005; 7:215-24

 

2006

 

 

2. Pawar RD, Patole PS, Wörnle M, Anders HJ.

Microbial nucleic acids pay a Toll in the kidney.

Am J Physiol Renal Physiol 2006; 291:F509-16

 

2007

 

 

3. Brzózka K, Pfaller C, Conzelmann KK.

Signal transduction in the type I interferon system and viral countermeasures.

Signal Transduction 2007; 7:5-19

 

 2008

 

 

4. Allam R, Anders HJ.

The role of innate immunity in autoimmune tissue injury.

Curr Opin Rheumatol 2008; 20:538-44

 

2009

 

5. Anders HJ.

Pseudoviral immunity-a novel concept for lupus

Trends Mol Med 2009; 15:553-61

 

6. Rieder M, Conzelmann KK.

Rhabdovirus evasion of the interferon system.

J Interferon Cytokine Res 2009; 29:499-509.

 

2010

 

7. Anders HJ, Lichtnekert J, Allam R.

Interferon –alpha and –beta in renal inflammation.

Kidney Int 2010; 77:848-54 (JIF 6,4)

 

8. Anders HJ.

Toll-like receptors and danger signaling in kidney injury.

J Am Soc Nephrol 2010, in press. (JIF 7,5)

 

9. Anders HJ, Schlondorff D.

Innate immune receptors and autophagy. Implications for autoimmune kidney injury.

Kidney Int 2010; 78:29-37 (JIF 6,4)

 

10. Schmidt A, Endres S, Rothenfusser S.

Viral nucleic acid pattern recognition by RIG-I-like helicases.

Journal of Moleculare Medicine 2010 (JIF 5,0)

 

11. Anders HJ, Muruve D.

The inflammasomesand Kidney disease.

J Am Soc Nephrol 2010; 21:1270-4 (JIF 7,8)

12. Robson NC, Hoves S, Maraskovsky E, Schnurr M.

Presentation of tumour antigens by dendritic cells and challenges faced.

Curr Opin Immunol 2010; 22(1):137-44. (JIF 9,5)

 

 

2011

 

13. Rieder M, Conzelmann KK.

Interferon in rabies virus infection.

Adv Virus Res 2011; 79:91-114 (JIF 4,8)

 

14. Schmidt A, Rothenfusser S, Hopfner KP.

Sensing of viral nucleic acids by RIG-I: From translocation to translation.

Eur J Cell Biol 2011; 91:78-85 (JIF 3,6)

 

15. Anders HJ, Kurts C.

Innate immunity and dendritic cells in kidney disease and the nobel prize.

J Am Soc Nephrol 2011; 22:2139-41 (JIF 8,3)

 

2012

 

16. Migliorini A, Anders HJ.

A novel pathogenetic concept - antiviral immunity in lupus nephritis.

Nat Rev Nephrol 2012; 8:183–189 (JIF 4,9)

 

17. Lech M, Römmele C, Anders HJ.

Pentraxins in nephrology. C-reactive protein, serum amyloid P, and pentraxin-3.

Nephrol Dial Transplant 2013; 28:803-11. (JIF 3,6)

 

18. Kulkarni OP, Anders HJ.

Lupus nephritis. How latest insights into its pathogenesis promote novel therapies.

Curr Opin Rheumatol 2012, 24:457-65. (JIF 4,5)

 

19. Lech M, Gröbmayr R, Weidenbusch M, Anders HJ.

Tissues Use Resident Dendritic Cells and Macrophages to Maintain Homeostasis and to Regain Homeostasis upon Tissue Injury: The Immunoregulatory Role of Changing Tissue Environments.

Mediators Inflamm 2012; 2012:951390. (JIF 3,3)

 

20. Weidenbusch M, Anders HJ.

Tissue microenvironments define and get reinforced by macrophage phenotypes in homeostasis or during inflammation, repair and fibrosis

J Innate Immun 2012; 4:463-77 (JIF 2,6)

 

2013

 

21. Anders HJ, Andersen K, Stecher B.

The intestinal microbiota, a leaky gut, and abnormal immunity in kidney disease.

Kidney Int 2013; 83:1010-6. (JIF 6,6)

 

22. Kurts C, Panzer U, Anders HJ, Rees AJ.

The immune system and kidney disease: basic concepts and clinical implications.

Nat Rev Immunol 2013; 13:738-53 (JIF 33,1).

 

23. Günthner R, Anders HJ.

Interferon-regulatory factors determine macrophage phenotype polarization.

Mediators Inflamm 2013; 2013:731023 (JIF 3,9)

 

2014

 

24. Anders HJ, Fogo AB.

Immunopathology of lupus nephritis.

Semin Immunopathol 2014; 36:443-59. (JIF 5,4)

 

25. Allam R, Kumar SV, Darisipudi MN, Anders HJ.

Extracellular histones in tissue injury and inflammation.

J Mol Med (Berl) 2014; 92:465-72 (JIF 4,8)

 

26. Liu Y, Anders HJ.

Lupus nephritis: from pathogenesis to targets for biologic treatment.

Nephron Clin Pract 2014;128:224-31 (JIF 1,7)

 

27. Heppt MV, Tietze JK, Graf SA, Berking C.

Combination therapy of melanoma using kinase inhibitors.

Curr Opin Oncol 2015; 27:134-40. (JIF 3,8)

 

2015

 

28. Schnurr M, Duewell P, Bauer C, Rothenfusser S, Lauber K, Endres S, Kobold S.

Strategies to relieve immunosuppression in pancreatic cancer.

Immunotherapy 2015; (in press) (JIF 2,4)

29. Anders HJ, Weidenbusch M, Rovin B.

Unmet medical needs in lupus nephritis: solutions through evidence-based, personalized medicine.

Clin Kidney J 2015; 8(5):492-502. 

 

 

E Bücher

 

1. Anders HJ, Migliorini A.

Innate DNA and RNA Recognition

Springer-Verlag GmbH; 2014.

 

5.1h Buchkapitel

1. Hoffmann R, Lenk E, Heesemann J.

Transcriptional profiling of Yersinia enterocolitica-host cell interactions.

In: Yersinia Systems Biology and Control, p. 59 - 67. Ed.: E. Carniel and BJ Hinnebusch. Caister Academic Press; 2012

 

2. Schmidt A, Linder A, Linder N, Rothenfusser S.

Isolation of RIG-I-Associated RNAs from Virus-Infected Cells. In: Innate DNA and RNA recognition, p.37 – 44. Ed.: HJ. Anders, A. Migliorini.

Springer-Verlag GmbH; 2014.

 

3. Romoli S, Migliorini A.

Analysis of Nucleic Acid-Induced Nonimmmune Cell Death In Vitro. In: Innate DNA and RNA recognition, p.77 – 86. Ed.: HJ. Anders, A. Migliorini.

Springer-Verlag GmbH; 2014.

4. Koelzer VH, Anz D.

A Modular Approach to Suppression Assays: TLR Ligands, Conditioned Medium, and Viral Infection. In: Innate DNA and RNA recognition, p.107 – 120. Ed.: HJ. Anders, A. Migliorini.

Springer-Verlag GmbH; 2014.

 

5. Kaeuferle T, Bartel S, Dehmel S, Krauss-Etschmann S.

MicroRNA Methology: Advances in miRNA Technologies. In: Innate DNA and RNA recognition, p.121 – 132. Ed.: HJ. Anders, A. Migliorini.

Springer-Verlag GmbH; 2014.

 

6. Rapp M, Anz D, Schnurr M.

Isolation of Intratumoral Leukocytes of TLR-Stimulated Tumor-Bearing Mice. In: Innate DNA and RNA recognition, p.175 – 180. Ed.: HJ. Anders, A. Migliorini.

Springer-Verlag GmbH; 2014.

 

7. Matheis F, Besch R.

Bifunctional siRNAs for Tumor Therapy. In: Innate DNA and RNA recognition, p.181 – 192. Ed.: HJ. Anders, A. Migliorini.

Springer-Verlag GmbH; 2014.

5.2 Zwanzig wichtigste Publikationen des Graduiertenkollegs

 

1. Hornung V, Ellegast J, Kim S, Brzozka K, Jung A, Kato H, Poeck H, Akira S, Conzelmann KK, Schlee M, Endres S, Hartmann G.

5’-triphosphate RNA is the ligand for RIG-I.

Science 2006; 314:994-997. (JIF 26,4)

 

2. Bourquin C, Schmidt L, Hornung V, Wurzenberger C, Anz D, Sandholzer N, Schreiber S, Voelkl A, Hartmann G, Endres S.

Immunostimulatory RNA oligonucleotides trigger an antigen-specific cytotoxic T-cell and IgG2a response.

Blood 2007; 109:2953-60. (JIF 10,4)

 

3. Bourquin C, Anz D, Zwiorek K, von der Borch P, Wurzenberger C, Lanz A, Golic M, Fuchs S, Winter G, Coester C, Endres S.

Targeting CpG oligonucleotides to the lymph node by nanoparticles elicits efficient antitumoral immunity.

J Immunol 2008; 181:2990-8. (JIF 7,3)

 

4. Poeck H, Besch R, Maihoefer C, Renn M, Tormo D, Shulga Morskaya S, Kirschnek S, Gaffal E, Landsberg J, Hellmuth J, Schmidt A, Anz D, Bscheider M, Schwerd T, Berking C, Bourquin C, Kalinke U, Kremmer E,

Kato H, Akira S, Meyers R, Häcker G, Neuenhahn M, H. Busch D, Rothenfusser S, Prinz M, Hornung V, Endres S, Tüting T, Hartmann G.

5 ́-triphosphate-siRNA: turning gene silencing and RIG-I activation against melanoma.

Nat Med 2008; 14:1256-63. (JIF 26,4)

 

5. Cui S, Eisenächer K, Kirchhofer A, Brzózka K, Lammens A, Lammens K, Fujita T, Conzelmann KK, Krug A, Hopfner KP.

The C-terminal regulatory domain is the RNA 5'-triphosphate sensor of RIG-I.

Mol Cell 2008; 29:169-179. (JIF 14,0)

 

6. Gack MU, Kirchhofer A, Shin YC, Inn KS, Liang C, Cui S, Myong S, Ha T, Hopfner KP, Jung JU.

Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction.

Proc Natl Acad Sci U S A 2008;105:16743-8. (JIF 9,6)

 

7. Hornung V, Bauernfeind F, Halle A, Samstad E, Kono H, Rock K, Fitzgerald K, Latz E.

Silica crystals and aluminum salts mediate NALP-3 inflammasome activation via phagosomal destabilization.

Nat Immunol 2008; 9:847-56. (JIF 27,6)

v

8. Michallet MC, Meylan E, Ermolaeva MA, Vazquez J, Rebsamen M, Curran J, Poeck H, Bscheider M, Hartmann G, König M, Kalinke U, Pasparakis M, Tschopp J.

TRADD protein is an essential component of the RIG-like helicase antiviral pathway.

Immunity 2008; 28:651-61. (JIF 18,0)

 

9. Myong S, Cui S, Cornish PV, Kirchhofer A, Gack MU, Jung JU, Hopfner KP, Ha T.

Cytosolic viral sensor RIG-I is a 5'-triphosphate-dependent translocase on double-stranded RNA.

Science 2009; 323:1070-4. (JIF 26,4)

 

10. Schmidt A*, Schwerd T*, Hamm W*, Hellmuth JC, Cui S, Wenzel M, Hoffmann F, Michallet MC, Besch R, Hopfner KP, Endres S, Rothenfusser S.

5’-triphosphate RNA requires base-paired structures to activate anti-viral signaling via RIG-I

Proc Natl Acad Sci USA 2009; 106:12067-72. (JIF 9,5) * equal contribution

 

11. Besch R*, Poeck H*, Hohenauer T, Senft D, Haecker G, Berking C, Hornung V, Endres S, Ruzicka T, Rothenfusser S*, Hartmann G*.

Proapoptotic signalling by RIG-I and MDA-5 results in tumorspecific apoptosis independent of type I interferons in melanoma.

J Clin Invest 2009; 119:2399-411. (JIF 16,9) * equal contribution

 

12. Kirchhofer A, Helma J, Schmidthals K, Frauer C, Cui S, Karcher A, Pellis M, Muyldermans S, Casas Delucchi C, Cardoso CM, Leonhardt H, Hopfner KP, Rothbauer U.

Modulation of protein properties in living cells using nanobodies.

Nat Struct Mol Biol 2010; 17:133-8. (JIF 11,0)

 

13. Duewell P, Kono H, Rayner KJ, Sirois CM, Vladimer G, Bauernfeind FG, Abela GS, Franchi L, Nuñez G, Schnurr M, Espevik T, Lien E, Fitzgerald KA, Rock KL, Moore KJ, Wright SD, Hornung V, Latz E.

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals.

Nature 2010; 464:1357-61. (JIF 31,4)

 

14. Bauer C, Duewell P, Mayer C, Lehr HA, Fitzgerald KA, Dauer M, Tschopp J, Endres S, Latz E, Schnurr M.

Colitis induced in mice with dextran sulfate sodium (DSS) is mediated by the NLRP3 inflammasome.

Gut 2010; 59:1192-9. (JIF 9,8)

 

15. Poeck H, Bscheider M, Gross O, Finger K, Roth S, Rebsamen M, Hannesschläger N, Schlee M, Rothenfusser S, Barchet W, Kato H, Akira S, Inoue S, Endres S, Peschel Ch, Hartmann G, Hornung V, Ruland J.

Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1 beta production.

Nat Immunol 2010; 11:63-9. (JIF 25,1)

 

16. Zoglmeier C, Bauer H, Noerenberg D, Wedekind G, Bittner P, Sandholzer N, Rapp M, Anz D, Endres S, Bourquin C.

CpG blocks immune suppression by myeloid-derived suppressor cells in tumor-bearing mice.

Clin Cancer Res 2011; 17:1765-75. (JIF 6,7)

 

17. Motz C, Schuhmann KM, Kirchhofer A, Moldt M, Witte G, Conzelmann KK, Hopfner KP.

Paramyxovirus V Proteins Disrupt the Fold of the RNA Sensor MDA5 to Inhibit Antiviral Signaling.

Science 2013; 339:690-3. (JIF 31,2)

 

18. Ellermeier J, Wei J, Duewell P, Hoves S, Stieg MR, Adunka T, Noerenberg D, Anders HJ, Mayr D, Poeck H, Hartmann G, Endres S, Schnurr M.

Therapeutic efficacy of bifunctional siRNA combining TGF-β1 silencing with RIG-I activation in pancreatic cancer.

Cancer Res 2013; 73:1709-20. (JIF 7,9)

 

19. Hoffmann F, Schmidt A, Dittmann Chevillotte M, Wisskirchen C, Hellmuth JC, Willms S, Gilmore RH, Glas J, Folwaczny M, Müller T, Berg T, Spengler U, Fitzmaurice K, Kelleher D, Reisch N, Rice CM, Endres S,

Rothenfusser S.

Polymorphisms in MDA-5 link protein function to clearance of hepatitis C virus

Hepatology 2015; 61:460-70. (JIF 11,2)

 

20. Kobold S, Steffen J, Chaloupka M, Grassmann S, Henkel J, Castoldi R, Zeng Y, Chmielewski M, Schmollinger J, Schnurr M, Rothenfußer S, Schendel DJ, Abken H, Sustmann C, Niederfellner CG, Klein C,

Bourquin C, Endres S.

Selective bispezific T cell recruiting antibody enhances anti-tumor activity of adoptive T cell transfer.

J Natl Cancer Inst 2015; 107:364 (JIF 15.2)