Jaw Bone and Osteonecrosis of the Jaw
Background
| Bisphosphonate related osteonecrosis of the jaw is a new entity of tissue necrosis first described in 2003. It is most frequently diagnosed in patients suffering from bone metastasis and receiving bisphosphonates in the course of their supportive oncologic treatment intravenously. Patients receiving an oral bisphosphonate therapy due to osteoporosis are also affected by this form of osteonecrosis, but the incidence is a magnitude lower. The clinical hallmark of the disease is exposed bone in the oral in the mandible or the maxilla with no healing tendency. If diagnosed or treated with delay severe complications such as pathological fracture of the jaw can occur. The pathogenesis of the disease is still poorly understood. |  |
Current Projects
- Evaluation of the novel technique of fluorescence guided bone resection (clinical project)
(biochemical, biophysical and morphological characterisation) - Collection of epidemiologic data (clinical project)
- Establishment of a large animal model for bisphosphonate related osteonecrosis (cooperation with the Technical University of Munich and University of Rostock).
- Cell culture experiments with focus on the influence of the pH value and the bisphosphonate derivate on the onset of the ostoenecrosis
Group Leader
|
Sven Otto, DDS Contact: Sven.Otto@med.uni-muenchen.de |
||
|
Christoph Pautke, MD DDS, has studied medicine in Göttingen (Germany) and London (UK) as well as dentistry in Göttingen and Munich (Germany). He started working on bone regeneration in 2000 in the "Tissue Engineering of Bone"-group at the Department of Surgery – University of Munich. He specialized in the field of Oral and Maxillofacial Surgery in 2007 (Technichal University of Munich, Germany). Since 2009 he is consultant and associate professor in the Department of Oral and Maxillofacial Surgery, University of Munich, and active member of the research laboratory Experimed of Professor Schieker. |
 |
