Bone
Background
|
Due to their plasticity and their ability to self-renew, mesenchymal stem cells (hMSC) are ideally suited for different medical applications such as tissue engineering of bone. Intensive research has revealed sequential steps in the osteogenic differentiation pathway starting from mesenchymal stem cells over progenitor cells and ending with terminally differentiated osteoblasts. Yet, hMSCs are usually cultured in heterogeneous cell populations with analytical drawbacks. Therefore, our focus lies in investigation of these cells on single cell level with various innovative methodological tools. |
 |
Current Projects
- Identification of subpopulations of mesenchymal stem cells on single cell level
(biochemical, biophysical and morphological characterisation) - Cell traces of adherent stem cells
- Cell division over time by time lapse analysis
- Adipogenic – osteogenic transdifferentiation
- Identification of hMSC in patients with osteoporotic fracture
Group Leader
|
Matthias Schieker, MD, Surgeon, studied medicine in Munich, London and Boston. He started working on bone regeneration in 1996 during his thesis at the medical faculty of the LMU. In 2000 he founded the "Tissue Engineering of Bone"-group at the Department of Surgery – Downtown, LMU Munich. After having finished his training to become a certified surgeon in 2005, he became Head of Research at the Department of Surgery and founded the laboratory of Experimental surgery and regenerative Medicine (ExperiMed). Matthias Schieker is Professor of Regenerative Medicine with focus on muskuloskelettal tissues since February 2010 at the LMU Munich.
In addition to his research at the LMU, Matthias Schieker is clinical consultant of osteoporosis and orthogeriatrics at the Department of Surgery (LMU) and is member of the steering committee of the interdisciplinary clinical osteoporosis center (LMU). Contact: Matthias.Schieker@med.uni-muenchen.de Info: www.experimed.de, www.alterstraumatologie.de, www.osz.klinikum.uni-muenchen.de |
 |
