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Selected Publications

Wuchereria bancrofti infection is linked to systemic activation of CD4 and CD8 T cells.
Kroidl I, Chachage M, Mnkai J, Nsojo A, Berninghoff M, Verweij JJ, Maganga L, Ntinginya NE, Maboko L, Clowes P, Hoelscher M, Saathoff E and Geldmacher C.
PLoS Negl Trop Dis. 2019


Envelope-specific epitope recognition patterns of HIV vaccine-induced IgG antibodies are linked to immunogen structure and sequence.
Nadai Y, Held K, Joseph S, Ahmed MIM, Hoffmann VS, Peterhoff D, Missanga M, Bauer A, Joachim A, Reimer U, Zerweck J, McCormack S, Cope AV, Tatoud R, Shattock RJ, Robb ML, Sandstroem EG, Hoelscher M, Maboko L, Bakari M, Kroidl A, Wagner R, Weber J, Pollakis G, Geldmacher C.
Front Immunol. 2019


Communication of CD8 + T Cells With Mononuclear Phagocytes in Multiple Sclerosis.

Kojevic Sabolek M, Held K, Beltrán E, Niedl AG, Meinl E, Hohlfeld R, Lassmann H, Dornmair K
Ann Clin Transl Neurol. 2019


Phenotypic Changes on Mycobacterium Tuberculosis-Specific CD4 T Cells as Surrogate Markers for Tuberculosis Treatment Efficacy.
Ahmed MIM, Ntinginya NE, Kibiki G, Mtafya BA, Semvua H, Mpagama S, Mtabho C, Saathoff E, Held K, Loose R, Kroidl I, Chachage M, von Both U, Haule A, Mekota AM, Boeree MJ, Gillespie SH, Hoelscher M, Heinrich N, Geldmacher C.
Front Immunol. 2018

 

Preferential Targeting of Conserved Gag Regions after Vaccination with a Heterologous DNA prime - Modified Vaccinia Ankara (MVA) boost HIV-1 vaccine regimen.
Bauer A, Podola L, Mann P, Missanga M, Haule A, Sudi L, Nilsson C, Kaluwa B, Lueer C, Mwakatima M, Munseri PJ, Maboko L, Robb ML, Tovanabutra S, Kijak G, Marovich M, McCormack S, Joseph S, Lyamuya E, Wahren B, Sandström E, Biberfeld G, Hoelscher M, Bakari M, Kroidl A, Geldmacher C.
J Virol. 2017

 

Effect of Wuchereria bancrofti infection on HIV incidence in southwest Tanzania: a prospective cohort study.
Kroidl I, Saathoff E, Maganga L, Makunde WH, Hoerauf A, Geldmacher C, Clowes P, Maboko L, Hoelscher M.
Lancet. 2016

 

CD25+ FoxP3+ Memory CD4 T Cells Are Frequent Targets of HIV Infection In Vivo.
Chachage M, Pollakis G, Kuffour EO, Haase K, Bauer A, Nadai Y, Podola L, Clowes P, Schiemann M, Henkel L, Hoffmann D, Joseph S, Bhuju S, Maboko L, Sarfo FS, Eberhardt K, Hoelscher M, Feldt T, Saathoff E, Geldmacher C.
J Virol. 2016

 

CTLA4 as Immunological Checkpoint in the Development of Multiple Sclerosis.
Gerdes LA*, Held K*, Beltran E*, Berking C, Prinz JC, Junker A, Tietze JK, Ertl-Wagner B, Straube A, Kuempfel T, Dornmair K*, Hohlfeld R*
Ann Neurol. 2016

 

Commentary: First-in-human trial of a live-attenuated Mycobacterium tuberculosis vaccine.
Geldmacher C, Hatherill M.
Lancet Respir Med. 2015

 

Commentary: Early Identification of Progressive TB Disease Using Host Biomarkers.
Rachow A, Heinrich N, Geldmacher C
EBioMedicine. 2015

 

αβ T-cell receptors from multiple sclerosis brain lesion show MAIT cell-reladed features.
Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltrán E, Schmidt S, Rühl G, Ng JKM, Engerer P, Moser M, Klinkert WEF, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, Dornmair K
Neurol N2. 2015

 

Assessment of the novel T-cell activation marker-tuberculosis assay for diagnosis of active tuberculosis in children: a prospective proof-of-concept study.
Portevin D, Moukambi F, Clowes P, Bauer A, Chachage M, Ntinginya NE, Mfinanga E, Said K, Haraka F, Rachow A, Saathoff E, Mpina M, Jugheli L, Lwilla F, Marais BJ, Hoelscher M, Daubenberger C, Reither K*, Geldmacher C*.
Lancet Infect Dis. 2014

 

Helminth-Associated Systemic Immune Activation and HIV Co-receptor Expression: Response to Albendazole/Praziquantel Treatment.
Chachage M, Podola L, Clowes P, Nsojo A, Bauer A, Mgaya O, Kowour D, Froeschl  G, Maboko L, Hoelscher M, Saathoff E, Geldmacher C.
PLoS Negl Trop Dis. 2014

 

Interaction between HIV and Mycobacterium tuberculosis: HIV-1-induced CD4 T-cell depletion and the development of active tuberculosis.
Geldmacher C, Zumla A, Hoelscher M.
Curr Opin HIV AIDS. 2012

 

Pathogen-specific T cell depletion and reactivation of opportunistic pathogens in HIV infection.
Geldmacher C, Koup RA.
Trends Immunol. 2012 May;33(5):207-14

 

Expression of herpes simplex virus 1-encoded microRNAs in human trigeminal ganglia and their relation to local T-cell infiltrates.
Held K, Junker A, Dornmair K, Meinl E, Sinicina I, Brandt T, Theil D, Derfuss T
J Virol. 2011

 

Preferential infection and depletion of Mycobacterium tuberculosis-specific CD4 T cells after HIV-1 infection.
Geldmacher C, Ngwenyama N, Schuetz A, Petrovas C, Reither K, Heeregrave EJ, Casazza JP, Ambrozak DR, Louder M, Ampofo W, Pollakis G, Hill B, Sanga E, Saathoff E, Maboko L, Roederer M, Paxton WA, Hoelscher M, Koup RA.
J Exp Med. 2010

 

Minor viral and host genetic polymorphisms can dramatically impact the biologic outcome of an epitope-specific CD8 T-cell response.
Geldmacher C, Metzler IS, Tovanabutra S, Asher TE, Gostick E, Ambrozak DR, Petrovas C, Schuetz A, Ngwenyama N, Kijak G, Maboko L, Hoelscher M, McCutchan F, Price DA, Douek DC, Koup RA.
Blood. 2009

 

SIV-specific CD8+ T cells express high levels of PD1 and cytokines but have impaired proliferative capacity in acute and chronic SIVmac251 infection.
Petrovas C, Price DA, Mattapallil J, Ambrozak DR, Geldmacher C, Cecchinato V, Vaccari M, Tryniszewska E, Gostick E, Roederer M, Douek DC, Morgan SH, Davis SJ, Franchini G, Koup RA.
Blood. 2007

 

CD8 T-cell recognition of multiple epitopes within specific Gag regions is associated with maintenance of a low steady-state viremia in human immunodeficiency virus type 1-seropositive patients.
Geldmacher C, Currier JR, Herrmann E, Haule A, Kuta E, McCutchan F, Njovu L, Geis S, Hoffmann O, Maboko L, Williamson C, Birx D, Meyerhans A, Cox J, Hoelscher M.
J Virol. 2007