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Buruli Ulcer Disease

Head: PD Dr. G. Bretzel

Cooperations: Bernhard Nocht Institut für Tropenmedizin, Hamburg; Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana; Agogo Presbyterian Hospital, Agogo, Ghana; Dunkwa Government Hospital, Dunkwa, Ghana; St. Martin’s Hospital, Agroyesum G

Grants: Volkswagen Foundation, European Commission

Description:

Summary: In cooperation with the  Kumasi Centre for Collaborative Research in Tropical Medicine, Kumasi, Ghana (KCCR), the Bernhard Nocht Institute for Tropical Medicine, Hamburg (BNITM), and four local treatmentv centres for Buruli-Ulcer disease (BUD) a network for the early diagnosis of BUD has been established in Ghana. Within a reserach project supported by the VW foundation a dry-reagent based PCR as a novel tool for the laboratory confirmation of clinically diagnosed M. ulcerans disease has been developed.

Within a multidisciplinary research EC project for the improvement of BUD control in Africa the following reserch topics have been investigated by the Munich working group:

  • Investigations on the step wise diagnosis of BUD
  • Comparison of defferent methods for the diagnosis of BUD
  • External quality control of diagnostic lab procedures in Ghana
  • Investigations on the curative excision of pre-ulcer lesions
  • Sequence analysis of the  rpoB gene of M. ulcerans from clinical lesions

 

Coworkers:

Dr. hum. biol. V. Siegmund, PD Dr. med. J. Nitschke, E. Fleischmann, A. Tilly, D. Brieske, M. Beissner, Dr. med. KH. Herbinger